Results 11 to 20 of about 491 (67)

Protective Role of AMPK against PINK1^B9 Flies' Neurodegeneration with Improved Mitochondrial Function. [PDF]

Parkinsons Dis, 2023
Adenosine 5′‐monophosphate‐activated protein kinase (AMPK)’s effect in PTEN‐induced kinase 1 (PINK1) mutant Parkinson’s disease (PD) transgenic flies and the related mechanism is seldom studied. The classic MHC-Gal4/UAS PD transgenic flies was utilized to generate the disease characteristics specifically expressed in flies’ muscles, and Western blot ...
Xiang G, Wen X, Wang W, Peng T, Wang J, Li Q, Teng J, Cui Y.   +7 more
europepmc   +2 more sources

Interleukin‐7 improves the fitness of regulatory T cells for adoptive transfer

Immunology, Volume 170, Issue 4, Page 540-552, December 2023., 2023
Regulatory T cell (Treg) expanded in the presence of interleukin‐7 (IL‐7, IL‐7M) display a CD45RA+CD62L+CD95+ phenotype and are less suppressive that Treg expanded with the standard method (StM). Once infused in vivo IL‐7M‐Treg persist longer and showed similar suppressive activity compared to StM‐Treg.
Ilaria Cosorich, Jessica Filoni, Carla Di Dedda, Arianna Ferrari, Tatiana Jofra, Susanna Cesarano, Chiara Bonini, Lorenzo Piemonti, Paolo Monti   +8 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

Prognostic value of non‐invasive scores based on liver stiffness measurement, spleen diameter and platelets in HIV‐infected patients

Liver International, Volume 43, Issue 7, Page 1427-1439, July 2023., 2023
Abstract Background and Aims People living with HIV (PLWH) are at high risk for advanced chronic liver disease and related adverse outcomes. We aimed to validate the prognostic value of non‐invasive scores based on liver stiffness measurement (LSM) and on markers of portal hypertension (PH), namely platelets and spleen diameter, in PLWH.
Amine Benmassaoud, Juan Macias, Adèle Delamarre, Anaïs Corma‐Gomez, Giovanni Guaraldi, Jovana Milic, Jürgen K. Rockstroh, Kathrin Van Bremen, Emmanuel Tsochatzis, Akhilesh Mulay, Jennifer Price, Lucy J. Garvey, Maud Lemoine, Dana Kablawi, Bertrand Lebouche, Marina B. Klein, Luz R. Ballesteros, Christopher Boesecke, Filippo Schepis, Sanjay Bhagani, Graham Cooke, Annalisa Berzigotti, Kyoko Hirose, Juan A. Pineda, Agnihotram V. Ramanakumar, Victor De‐Ledinghen, Sahar Saeed, Giada Sebastiani   +27 more
wiley   +1 more source

Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC. [PDF]

Eur J Immunol
We here provide detailed protocols for isolating single cell suspension from human nonlymphoid tissues, such as gingiva, lung, intestine, skin, and different tumor tissues as well as tumor‐draining lymph nodes. Further, we provide gating strategies for flow cytometric analysis of human DC subpopulations in diverse nonlymphoid tissues.
Dudziak D, Heger L, Agace WW, Bakker J, de Gruijl TD, Dress RJ, Dutertre CA, Fenton TM, Fransen MF, Ginhoux F, Heyman O, Horev Y, Hornsteiner F, Kandiah V, Kles P, Lubin R, Mizraji G, Prokopi A, Saar O, Sopper S, Stoitzner P, Strandt H, Sykora MM, Toffoli EC, Tripp CH, van Pul K, van de Ven R, Wilensky A, Yona S, Zelle-Rieser C.   +29 more
europepmc   +2 more sources

Variability in nutrient composition of the edible long‐horned grasshopper (Ruspolia differens) in Uganda and its potential in alleviating food insecurity

Food Science &Nutrition, Volume 11, Issue 6, Page 3558-3574, June 2023., 2023
Long‐horned grasshoppers are consumed in over 21 African countries. Crude protein (28%–45%), crude fat (41%–54%), and energy (582–644 Kj/100 g) of grasshoppers are comparable to that of plant and animal origins. Grasshopper meal could be considered as functional food ingredients capable of supplying adequate essential macro‐ and micronutrients ...
Margaret Kababu, Collins K. Mweresa, Sevgan Subramanian, James P. Egonyu, Chrysantus M. Tanga   +4 more
wiley   +1 more source

Dental Stem Cells SV40, a new cell line developed in vitro from human stem cells of the apical papilla

International Endodontic Journal, Volume 56, Issue 4, Page 502-513, April 2023., 2023
Abstract Aim To establish and fully characterize a new cell line from human stem cells of the apical papilla (SCAPs) through immortalization with an SV40 large T antigen. Methodology Human SCAPs were isolated and transfected with an SV40 large T antigen and treated with puromycin to select the infected population.
Diana Sanz‐Serrano, Cristina Sánchez‐de‐Diego, Montse Mercade, Francesc Ventura   +3 more
wiley   +1 more source

Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

Advanced Science, Volume 10, Issue 6, February 24, 2023., 2023
Tryptophan metabolites 5‐HT and 3‐HA act as potent radical trapping antioxidants to inhibit ferroptosis both in vitro and in vivo. Tryptophan metabolites‐mediated ferroptosis suppression is a new anti‐ferroptosis pathway distinct from cysteine‐mediated ferroptosis inhibition or any other classical anti‐ferroptotic pathways to facilitate tumor ...
Dong Liu, Chun‐hui Liang, Bin Huang, Xiao Zhuang, Weiwei Cui, Li Yang, Yinghong Yang, Yudan Zhang, Xiaolong Fu, Xiaoju Zhang, Lutao Du, Wei Gu, Xiangdong Wang, Chengqian Yin, Renjie Chai, Bo Chu   +15 more
wiley   +1 more source

Behavior analytic jargon does not seem to influence treatment acceptability ratings

Journal of Applied Behavior Analysis, Volume 55, Issue 4, Page 1294-1305, Fall 2022., 2022
Some have argued that behavior analysts have insulated themselves by eschewing the vernacular and adopting idiosyncratic and sometimes counterintuitive technical terms to describe their science and practice. Because of this, behavior analysis plays a minor role in psychology and related fields and effective behavior‐change interventions go unused.
Matthew P. Normand, Hailey E. Donohue
wiley   +1 more source