Results 1 to 10 of about 51,260 (112)

Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells. [PDF]

CNS Neurosci Ther
A cost‐effective and rapid in vitro model of Parkinson's disease was created using Wharton's Jelly‐derived mesenchymal stem cells by employing MPP+ iodide or A53T mutated α‐synuclein. ABSTRACT Main Problem The mechanism behind Parkinson's disease (PD) is still unclear, and a cure to stop its progression is yet to be found.
Gamit N, Patil M, Soumya BS, Dharmarajan A, Warrier S.   +4 more
europepmc   +2 more sources

Direct targeted therapy for MLL-fusion-driven high-risk acute leukaemias. [PDF]

Clin Transl Med, 2022
Direct inhibition of MLL‐fusion proteins is a potential therapeutic strategy. MLL‐fusion depletion screen identified disulfiram for its ability to ablate MLL‐fusion protein and block‐associated leukaemic phenotype. Disulfiram directly targets the CXXC domain that is essential for all MLL‐fusion proteins.
Cantilena S, Gasparoli L, Pal D, Heidenreich O, Klusmann JH, Martens JHA, Faille A, Warren AJ, Karsa M, Pandher R, Somers K, Williams O, de Boer J.   +12 more
europepmc   +2 more sources

Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC. [PDF]

Eur J Immunol
We here provide detailed protocols for isolating single cell suspension from human nonlymphoid tissues, such as gingiva, lung, intestine, skin, and different tumor tissues as well as tumor‐draining lymph nodes. Further, we provide gating strategies for flow cytometric analysis of human DC subpopulations in diverse nonlymphoid tissues.
Dudziak D, Heger L, Agace WW, Bakker J, de Gruijl TD, Dress RJ, Dutertre CA, Fenton TM, Fransen MF, Ginhoux F, Heyman O, Horev Y, Hornsteiner F, Kandiah V, Kles P, Lubin R, Mizraji G, Prokopi A, Saar O, Sopper S, Stoitzner P, Strandt H, Sykora MM, Toffoli EC, Tripp CH, van Pul K, van de Ven R, Wilensky A, Yona S, Zelle-Rieser C.   +29 more
europepmc   +2 more sources

The Limited Palette for Photonic Block‐Copolymer Materials: A Historical Problem or a Practical Limitation?

Angewandte Chemie, Volume 134, Issue 22, May 23, 2022., 2022
The self‐assembly of block‐copolymers into photonic films and pigments has drawn significant attention due to the tunability of the optical response. In this Scientific Perspective we identify and rationalize the limited range of monomers and polymerization methods employed to produce such structurally colored materials to date.
Zhen Wang, Chun Lam Clement Chan, Richard M. Parker, Silvia Vignolini   +3 more
wiley   +2 more sources

Guidelines for mouse and human DC functional assays

European Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
Conventional DC (cDC) represent a heterogenous family of professional antigen‐presenting cells. Basic functions common to all tissue‐resident cDC include antigen uptake, lymph node migration, and naive T cell priming to induce appropriate effector and regulatory T cell responses.
Björn E. Clausen, Lukas Amon, Ronald A. Backer, Luciana Berod, Tobias Bopp, Anna Brand, Sven Burgdorf, Luxia Chen, Meihong Da, Ute Distler, Regine J. Dress, Diana Dudziak, Charles‐Antoine Dutertre, Christina Eich, Anna Gabele, Melanie Geiger, Florent Ginhoux, Lucila Giusiano, Gloria J. Godoy, Ahmed E.I. Hamouda, Lukas Hatscher, Lukas Heger, Gordon F. Heidkamp, Lola C. Hernandez, Lukas Jacobi, Tomasz Kaszubowski, Wan Ting Kong, Christian H. K. Lehmann, Tamara López‐López, Karsten Mahnke, Dominik Nitsche, Jörg Renkawitz, Rifat A. Reza, Pablo J. Sáez, Laura Schlautmann, Madeleine T. Schmitt, Anna Seichter, Malte Sielaff, Tim Sparwasser, Patrizia Stoitzner, Giorgi Tchitashvili, Stefan Tenzer, Nounagnon R. Tochoedo, Damir Vurnek, Fabian Zink, Thomas Hieronymus   +45 more
wiley   +1 more source

Prodromal Parkinson's disease and the catecholaldehyde hypothesis: Insight from olfactory bulb organotypic cultures

The FASEB Journal, Volume 37, Issue 12, December 2023., 2023
Olfactory dysfunction is one of the most prevalent symptoms of Parkinson's disease preceding clinical onset by up to a decade. However, PD models focus mainly on motor symptoms and nigrostriatal degeneration. Here, we characterize cultured olfactory bulb organotypic slices and cells and explore the effect of DOPAL, a metabolite of dopamine.
Enrico Bagnoli, Alexandre Trotier, Jill McMahon, Leo R. Quinlan, Manus Biggs, Abhay Pandit, Una FitzGerald   +6 more
wiley   +1 more source

Guidelines for mouse and human DC generation

European Journal of Immunology, Volume 53, Issue 11, November 2023., 2023
The article on DC generation is part of the DC Guidelines article collection providing methods for the isolation of mouse and human cellular sources that can be cultured with different growth factors to generate the known subsets of DC. Abstract This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state ...
Manfred B. Lutz, Shafaqat Ali, Cindy Audiger, Stella E. Autenrieth, Luciana Berod, Venetia Bigley, Laura Cyran, Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez‐Grau, Lucila Giusiano, Gloria J. Godoy, Marion Heuer, Anne B. Krug, Christian H. K. Lehmann, Christian T. Mayer, Shalin H. Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke   +25 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

To preserve, release, and litigate: Dimensions of executive branch transparency

Presidential Studies Quarterly, Volume 53, Issue 2, Page 209-233, June 2023., 2023
Abstract Transparency is essential for public awareness of government activity and in holding officials accountable for their behavior and decisions. However, executives understandably have a desire to maintain autonomy over the flow of information outside of the executive branch, which can sometimes lead to a clash between government openness and ...
Gbemende E. Johnson, Tracey E. George
wiley   +1 more source