Results 31 to 40 of about 51,260 (112)

Chetracins E and F, cytotoxic epipolythiodioxopiperazines from the marine-derived fungus Acrostalagmus luteoalbus HDN13-530

, 2018
Two new epipolythiodioxopiperazines, named chetracins E and F (1 and 2), along with the known chetracin C (3), were isolated from the fungus Acrostalagmus luteoalbus HDN13-530. Their structures were elucidated based on the NMR, MS and CD data, as well as
Guihong Yu, Yanjuan Wang, Ri-lei Yu, Yanyan Feng, Lu Wang, Qian Che, Q. Gu, Dehai Li, Jing Li, T. Zhu   +9 more
semanticscholar   +1 more source

Potent Antiviral Activities of the Direct-Acting Antivirals ABT-493 and ABT-530 with Three-Day Monotherapy for Hepatitis C Virus Genotype 1 Infection

Antimicrobial Agents and Chemotherapy, 2015
ABT-493 is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor, and ABT-530 is an HCV NS5A inhibitor. These direct-acting antivirals (DAAs) demonstrated potent antiviral activity against major HCV genotypes and high barriers to ...
E. Lawitz, W. O'Riordan, A. Asatryan, B. Freilich, T. Box, J. Overcash, Sandra S. Lovell, T. Ng, Wei Liu, A. Campbell, Chih‐Wei Lin, Betty B. Yao, J. Kort   +12 more
semanticscholar   +1 more source

DOPA decarboxylase is an emerging biomarker for Parkinsonian disorders including preclinical Lewy body disease

Nature Aging, 2023
The diagnosis of Parkinsonian disorders is currently based on clinical criteria, which have limited sensitivity until most dopaminergic neurons are lost.
Joana B. Pereira, Atul Kumar, S. Hall, S. Palmqvist, E. Stomrud, Divya Bali, Piero Parchi, N. Mattsson-Carlgren, S. Janelidze, Oskar Hansson   +9 more
semanticscholar   +1 more source

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

Molecular Pain, 2014
BackgroundHIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active antiretroviral therapy (HAART). Evidence shows that painful HIV sensory neuropathy is influenced
Wenwen Zheng, Wan Huang, Shue Liu, R. Levitt, K. Candiotti, D. Lubarsky, S. Hao   +6 more
semanticscholar   +1 more source

Indigenous Peoples in the U.S., Sovereign Nations, and the DDC

, 2015
Claims of bias within the Dewey Decimal Classification (DDC) system in its treatment of indigenous peoples in the U.S. focus on marginalization through ghettoization, historicization, diasporization, and missing topics, such as the status of indigenous ...
Rebecca Green
semanticscholar   +1 more source

Comparative Analysis and Modeling of the Severity of Steatohepatitis in DDC-Treated Mouse Strains

PLoS ONE, 2014
Background Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammation ...
V. Pandey, M. Sultan, K. Kashofer, M. Ralser, V. Amstislavskiy, J. Starmann, I. Osprian, C. Grimm, Hendrik Hache, M. Yaspo, H. Sültmann, M. Trauner, H. Denk, K. Zatloukal, H. Lehrach, C. Wierling   +15 more
semanticscholar   +1 more source

The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism

Bioscience Reports, 2013
DDC (diethyldithiocarbamate) could block collagen synthesis in HSC (hepatic stellate cells) through the inhibition of ROS (reactive oxygen species) derived from hepatocyte CYP2E1 (cytochrome P450 2E1).
Tianhui Liu, Ping Wang, M. Cong, You-qing Xu, J. Jia, H. You   +5 more
semanticscholar   +1 more source

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

Nature Methods, 2021
C. Bohrer, Xinxing Yang, Shreyasi Thakur, Xiaoli Weng, Brian Tenner, Ryan J. McQuillen, Brian Ross, Matthew Wooten, Xin Chen, Jin Zhang, Elijah Roberts, M. Lakadamyali, Jie Xiao   +12 more
semanticscholar   +1 more source

l-DOPA Decarboxylase (DDC) Expression Status as a Novel Molecular Tumor Marker for Diagnostic and Prognostic Purposes in Laryngeal Cancer.

Translational Oncology, 2012
l-DOPA decarboxylase (DDC) plays an essential role in the enzymatic synthesis of dopamine and alterations in its gene expression have been reported in several malignancies.
Christos Patsis, Vasiliki Glyka, I. Yiotakis, E. Fragoulis, A. Scorilas   +4 more
semanticscholar   +1 more source

Periodic radio variabilities in NRAO 530: a jet-disc connection?

, 2013
Time series analysis techniques, Lomb-Scargle periodogram and weighted wavelet Z-transform, have been employed to search for year-time-scale periodicities from the radio light curves of a typical blazar NRAO 530.
T. An, W. Baan, Jun-yi Wang, Y. Wang, X. Hong   +4 more
semanticscholar   +1 more source