Results 11 to 20 of about 257,345 (161)

Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development. [PDF]

Mol Cell, 2022
Allele-specific expression of imprinted gene clusters is governed by gametic DNA methylation at master regulators called imprinting control regions (ICRs).
Juan AM, Foong YH, Thorvaldsen JL, Lan Y, Leu NA, Rurik JG, Li L, Krapp C, Rosier CL, Epstein JA, Bartolomei MS.   +10 more
europepmc   +2 more sources

Sex-Specific Phenotype-Performance Links: Divergent Correlations Between Morphology, Coloration, and Bite Force in the Mountain Dragon (<i>Diploderma vela</i>). [PDF]

Ecol Evol
D. vela exhibited pronounced sexual divergence in morphological traits, bite force, and body coloration, shaped by the interplay of three evolutionary mechanisms: sexual selection, fecundity advantage, and intraspecific niche divergence. These complementary, non‐exclusive processes collectively enhance adaptive fitness in the hot, dry river valley ...
Tan S, Li L, Gao W, Shu G, Guo P, Wu Y.
europepmc   +2 more sources

Deep Learning Reconstruction for ¹²⁹Xe Diffusion-Weighted MRI Enables Use of Natural Abundant Xenon and Improved Image Acceleration. [PDF]

Magn Reson Med
ABSTRACT Purpose (i) To assess whether 129Xe apparent diffusion coefficient (ADC) and diffusive length scale (LmD) metrics are quantitatively preserved with deep learning (DL) accelerated acquisition and reconstruction and (ii) to evaluate the feasibility of 129Xe diffusion weighted imaging with natural‐abundance xenon at increased acceleration factors.
Sundaresan R, Collier GJ, Stewart NJ, Chatterjee S, Venkatesan R, Wolber J, Wild JM.   +6 more
europepmc   +2 more sources

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +2 more sources

Peningkatan Efisiensi Tempat Penyimpanan Dokumen dengan Menggunakan Metode 5S dan Siklus PDCA di Industri Farmasi

Jurnal INTECH Teknik Industri Universitas Serang Raya, 2021
Pusat penelitian dan pengembangan obat yang ada di PT Dexa Medica adalah Dexa Development Center (DDC). Output dari DDC adalah dokumen dan disimpan dalam tempat penyimpanan yang dinamakan Kardex Remstar Shuttle XP 500.
MRR. Dwi Lindawati, Hery Hamdi Azwir
semanticscholar   +1 more source

Prevalence of DDC genotypes in patients with aromatic L-amino acid decarboxylase (AADC) deficiency and in silico prediction of structural protein changes.

Molecular Genetics and Metabolism, 2023
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive genetic disorder affecting the biosynthesis of dopamine, a precursor of both norepinephrine and epinephrine, and serotonin.
N. Himmelreich, M. Bertoldi, M. Alfadhel, M. Alghamdi, Y. Anikster, X. Bao, Fahad A. Bashiri, B. B. Zeev, Giovanni Bisello, A. Ceylan, Y. Chien, Y. Choy, S. Elsea, Lisa Flint, À. García-Cazorla, C. Gijavanekar, Emel Gümüş, M. Hamad, B. Hismi, T. Honzík, Oya Kuseyri Hübschmann, W. Hwu, Salvador Ibáñez-Micó, K. Jeltsch, N. Juliá-Palacios, C. Kasapkara, M. Kurian, K. Kuśmierska, Ning Liu, L. Ngu, John D. Odom, W. Ong, T. Opladen, Mari Oppebøen, Phillip L. Pearl, Belén Pérez, Roser Pons, A. Rygiel, Tan Ee Shien, R. Spaull, J. Sykut‐Cegielska, B. Tabarki, Trine Tangeraas, B. Thöny, T. Wassenberg, Y. Wen, Y. Yakob, J. G. Yin, J. Zeman, N. Blau   +49 more
semanticscholar   +1 more source

Spectrum of DDC variants causing aromatic l-amino acid decarboxylase (AADC) deficiency and pathogenicity interpretation using ACMG-AMP/ACGS recommendations.

Molecular Genetics and Metabolism, 2022
Pathogenic variants in dopa decarboxylase (DDC), the gene encoding the aromatic l-amino acid decarboxylase (AADC) enzyme, lead to a severe deficiency of neurotransmitters, resulting in neurological, neuromuscular, and behavioral manifestations clinically
N. Himmelreich, R. Montioli, S. Garbade, J. Kopesky, S. Elsea, C. Carducci, C. Voltattorni, N. Blau   +7 more
semanticscholar   +1 more source

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

Nature Methods, 2021
Single-molecule localization microscopy (SMLM) relies on the blinking behavior of a fluorophore, which is the stochastic switching between fluorescent and dark states. Blinking creates multiple localizations belonging to the same fluorophore, confounding
C. Bohrer, Xinxing Yang, Shreyasi Thakur, Xiaoli Weng, Brian Tenner, Ryan J. McQuillen, Brian L. Ross, Matthew Wooten, Xin Chen, Jin Zhang, Elijah Roberts, M. Lakadamyali, Jie Xiao   +12 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source