Results 11 to 20 of about 48,357 (114)

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +2 more sources

Protective Role of AMPK against PINK1^B9 Flies' Neurodegeneration with Improved Mitochondrial Function. [PDF]

Parkinsons Dis, 2023
Adenosine 5′‐monophosphate‐activated protein kinase (AMPK)’s effect in PTEN‐induced kinase 1 (PINK1) mutant Parkinson’s disease (PD) transgenic flies and the related mechanism is seldom studied. The classic MHC-Gal4/UAS PD transgenic flies was utilized to generate the disease characteristics specifically expressed in flies’ muscles, and Western blot ...
Xiang G, Wen X, Wang W, Peng T, Wang J, Li Q, Teng J, Cui Y.   +7 more
europepmc   +2 more sources

Prevalence of DDC genotypes in patients with aromatic L-amino acid decarboxylase (AADC) deficiency and in silico prediction of structural protein changes.

Molecular Genetics and Metabolism, 2023
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive genetic disorder affecting the biosynthesis of dopamine, a precursor of both norepinephrine and epinephrine, and serotonin.
N. Himmelreich, M. Bertoldi, M. Alfadhel, M. Alghamdi, Y. Anikster, X. Bao, F. Bashiri, B. Ben Zeev, Giovanni Bisello, A. Ceylan, Yin-Hsiu Chien, Y. Choy, S. Elsea, Lisa Flint, À. García-Cazorla, C. Gijavanekar, Emel Gümüş, Muddathir H. A. Hamad, B. Hismi, T. Honzík, Oya Kuseyri Hübschmann, W. Hwu, Salvador Ibáñez-Micó, K. Jeltsch, N. Juliá-Palacios, Ç. Kasapkara, M. Kurian, K. Kuśmierska, Ning Liu, L. Ngu, John D. Odom, W. Ong, T. Opladen, Mari Oppebøen, Phillip L. Pearl, Belén Pérez, Roser Pons, A. Rygiel, E. Tan, R. Spaull, J. Sykut-Cegielska, B. Tabarki, Trine Tangeraas, B. Thöny, T. Wassenberg, Y. Wen, Y. Yakob, J. G. Yin, J. Zeman, N. Blau   +49 more
semanticscholar   +1 more source

Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development

Molecules and Cells, 2022
Allele-specific expression of imprinted gene clusters is governed by gametic DNA methylation at master regulators called imprinting control regions (ICRs).
Aimee M. Juan, Y. Foong, J. L. Thorvaldsen, Y. Lan, N. Leu, J. Rurik, Li Li, Christopher J. Krapp, Casey L Rosier, J. Epstein, M. Bartolomei   +10 more
semanticscholar   +1 more source

Spectrum of DDC variants causing aromatic l-amino acid decarboxylase (AADC) deficiency and pathogenicity interpretation using ACMG-AMP/ACGS recommendations.

Molecular Genetics and Metabolism, 2022
Pathogenic variants in dopa decarboxylase (DDC), the gene encoding the aromatic l-amino acid decarboxylase (AADC) enzyme, lead to a severe deficiency of neurotransmitters, resulting in neurological, neuromuscular, and behavioral manifestations clinically
N. Himmelreich, R. Montioli, S. Garbade, J. Kopesky, S. Elsea, C. Carducci, C. Voltattorni, N. Blau   +7 more
semanticscholar   +1 more source

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-Meng Wu, Xu Chen, Qingbiao Xu, Lian-Sheng Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

Nature Methods, 2021
Single-molecule localization microscopy (SMLM) relies on the blinking behavior of a fluorophore, which is the stochastic switching between fluorescent and dark states. Blinking creates multiple localizations belonging to the same fluorophore, confounding
C. Bohrer, Xinxing Yang, Shreyasi Thakur, Xiaoli Weng, Brian Tenner, Ryan J. McQuillen, Brian L. Ross, Matthew Wooten, Xin Chen, Jin Zhang, Elijah Roberts, M. Lakadamyali, Jie Xiao   +12 more
semanticscholar   +1 more source

Multi-omics profiles refine L-dopa decarboxylase (DDC) as a reliable biomarker for prognosis and immune microenvironment of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
Background Increasing evidence indicates that L-dopa decarboxylase (DDC), which mediates aberrant amino acid metabolism, is significantly associated with tumor progression.
Kun Chang, Jia-Qi Su, Chuan-Yu Li, Aihetaimujiang Anwaier, Wang-Rui Liu, Wen-Hao Xu, Y. Qu, Hailiang Zhang, Ding-Wei Ye   +8 more
semanticscholar   +1 more source

HAWC J2227+610 and Its Association with G106.3+2.7, a New Potential Galactic PeVatron [PDF]

Astrophysical Journal, 2020
We present the detection of very-high-energy gamma-ray emission above 100 TeV from HAWC J2227+610 with the High-Altitude Water Cherenov Gamma-Ray Observatory (HAWC) observatory.
A. Albert, R. Alfaro, C. Alvarez, J. R. Angeles Camacho, J. C. Arteaga-Velázquez, K. Arunbabu, D. Rojas, H. A. Ayala Solares, V. Baghmanyan, E. Belmont-Moreno, S. Benzvi, C. Brisbois, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. D. de León, E. de la Fuente, L. Díaz-Cruz, B. Dingus, M. DuVernois, J. C. Díaz-Vélez, R. Ellsworth, K. Engel, C. Espinoza, K.-L. Fan, K. Fang, M. F. Alonso, H. Fleischhack, N. Fraija, A. Galván-Gámez, D. Garcia, J. A. García-González, F. Garfias, G. Giacinti, M. J. Martínez González, J. Goodman, J. P. Harding, S. Hernández, J. Hinton, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, William H. Lee, H. L. Vargas, J. Linnemann, A. Longinotti, G. Luis-Raya, J. Lundeen, K. Malone, S. Marinelli, O. Martinez, I. Martinez-Castellanos, J. Martínez-Castro, J. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, M. Newbold, M. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. P. Araujo, E. G. Pérez-Pérez, C. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, F. S. Greus, A. Sandoval, M. Schneider, H. Schoorlemmer, J. S. Franco, G. Sinnis, A. Smith, R. Springer, P. Surajbali, E. Tabachnick, M. Tanner, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, F. Ureña-Mena, L. Villaseñor, T. Weisgarber, A. Zepeda, Hong-Lei Zhou, C. de León, J. Álvarez   +99 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source