Results 21 to 30 of about 48,357 (114)

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

open access: yesPharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

Guidelines for mouse and human DC functional assays

open access: yesEuropean Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
Conventional DC (cDC) represent a heterogenous family of professional antigen‐presenting cells. Basic functions common to all tissue‐resident cDC include antigen uptake, lymph node migration, and naive T cell priming to induce appropriate effector and regulatory T cell responses.
Björn E. Clausen   +45 more
wiley   +1 more source

Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis

open access: yesInternational Journal of Nanomedicine, 2021
Background Exosomes secreted by peritoneal macrophages (pMφ) are deeply involved in the development of endometriosis (EMs). Exosomes can mediate cell-to-cell communication by transferring biological molecules.
Ting Liu   +5 more
semanticscholar   +1 more source

Deep Learning‐Enabled Multiplexed Point‐of‐Care Sensor using a Paper‐Based Fluorescence Vertical Flow Assay

open access: yesSmall, Volume 19, Issue 51, December 20, 2023., 2023
A multiplexed point‐of‐care serodiagnosis assay is reported to simultaneously quantify three biomarkers of acute cardiac injury. This point‐of‐care sensor includes a paper‐based fluorescence vertical‐flow‐assay processed by a low‐cost mobile reader, which quantifies the target biomarkers using neural networks within <15 min per test using 50 µL of ...
Artem Goncharov   +10 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander   +28 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

open access: yesBritish Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander   +27 more
wiley   +1 more source

Variability in nutrient composition of the edible long‐horned grasshopper (Ruspolia differens) in Uganda and its potential in alleviating food insecurity

open access: yesFood Science &Nutrition, Volume 11, Issue 6, Page 3558-3574, June 2023., 2023
Long‐horned grasshoppers are consumed in over 21 African countries. Crude protein (28%–45%), crude fat (41%–54%), and energy (582–644 Kj/100 g) of grasshoppers are comparable to that of plant and animal origins. Grasshopper meal could be considered as functional food ingredients capable of supplying adequate essential macro‐ and micronutrients ...
Margaret Kababu   +4 more
wiley   +1 more source

Understanding beliefs, preferences and actions amongst potential body donors

open access: yesAnatomical Sciences Education, Volume 16, Issue 2, Page 224-236, March/April 2023., 2023
Abstract Body donation is a prosocial act providing a unique learning experience to students, ultimately impacting on patient care and science. With an increasing number of training professionals, there is an increasing need for body donors, yet little is understood about donors' beliefs and preferences.
Claire F. Smith   +9 more
wiley   +1 more source

Protecting Earth and Space Industries from Orbital Debris: Implementing the Outer Space Treaty to Fill the Regulatory Vacuum in the FCC's Orbital Debris Guidelines

open access: yesAmerican Business Law Journal, Volume 60, Issue 1, Page 175-229, Spring 2023., 2023
The Outer Space Treaty (OST) is the foundation of all international space regulation. It establishes space as the province of all humankind and promotes its peaceful use and exploration for the benefit and in the interests of all countries. In 2020, the FCC released its “Mitigation of Orbital Debris in the New Space Age” guidelines for commercial ...
Michael B. Runnels
wiley   +1 more source

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

open access: yesInternational Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki   +7 more
semanticscholar   +1 more source

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