Results 11 to 20 of about 561 (68)
Brain Specific RagA Overexpression Triggers Depressive-Like Behaviors in Mice via Activating ADORA2A Signaling Pathway. [PDF]
Adv Sci (Weinh)The overexpression of brain‐specific RagA leads to depressive‐like behaviors, memory impairment, and hippocampal neuron loss in mice. This is accompanied by an upregulation of the adenosine A2a receptor (ADORA2A) and coordinated changes in the levels of depression‐related metabolites, proteins, and lncRNA.
Zhao J, Sun Y, Feng Y, Rong J.
europepmc +2 more sources
Small, EarlyView.Electron nanodiffraction mapping was used to determine that the 3D leg configuration of branched plasmonic AuAg nanostars is associated with the icosahedral symmetry of the star core, providing a deeper understanding of their growth mechanism and thus paving the way to the development of optimized synthesis protocols targeting optical enhancement ...
Leonardo M. Corrêa +7 more
wiley +1 more source
Brain Pathology, EarlyView.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Nickel‐based superalloys (Ni‐based superalloys) have attracted extensive attention in laser additive manufacturing (LAM) due to their capability to directly fabricate complex and high‐performance structural components. However, the rapid melting and solidification inherent to LAM result in intense thermal cycling, which induces high residual ...
Tianxiang Lin +9 more
wiley +1 more source
Towards a Sustainable Future: Addressing Climate Change and Promoting Sustainable Development
Sustainable Development, Volume 34, Issue S1, Page 226-247, January 2026.ABSTRACT This study aims to analyze policy research and global agreements on the decarbonization of economic development. Climate change and economic development are separate and equal, and strategies should separate responsibility from action. This will be required beyond the Kyoto and Paris agreements.
Woo‐Sik Sohn
wiley +1 more source
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 1, January 2026.ABSTRACT In the U.S., bovine milk is processed using thermal pasteurization to ensure microbial safety. However, this process alters the structure of heat‐sensitive bioactive proteins associated with the functional benefits of raw milk, including antimicrobial, immunomodulatory, and antioxidant proteins.
Rudy Sykora +5 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
The Journal of Physiology, Volume 603, Issue 19, Page 5751-5775, October 1, 2025.Abstract figure legend Uteroplacental insufficiency (growth restricted) or sham (Control) surgery was performed on embryonic day (E)18 in Wistar–Kyoto rats. Female F1 offspring were mated and restricted dams received daily metformin, insulin or vehicle from E13.
Dayna A. Zimmerman +11 more
wiley +1 more source
Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications
MedComm, Volume 6, Issue 9, September 2025.Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen +4 more
wiley +1 more source