Results 1 to 10 of about 896 (65)

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication. [PDF]

Angew Chem Int Ed Engl
Shewanella oneidensis and Bacillus subtilis, both harboring prophages, reveal a novel biosynthetic route to scalable and programmable DNA superstructures in flower‐ and wire‐like shapes, respectively. Activation of prophages is achieved via 3‐hour starvation and monitored using reporter strains.
Minero GAS, Mørkholt Lund L, Hyldgaard Klausen L, Ajunwa OM, Dong M, Meyer RL, Birkedal V, Thormann K.   +7 more
europepmc   +3 more sources

Mesocorticolimbic Dopamine-Reward Tract Alterations and the 'Dark Side' of Methamphetamine Addiction. [PDF]

Addict Biol
Nondrug rewards are commonly discounted, and the motivation to pursue healthful, drug‐free activities is often diminished in addiction. This study found that people with problematic methamphetamine‐use experience exhibited microstructural alterations in bundles of a mesocorticolimbic white‐matter tract implicated in reward processing.
Roy RJ, Wakabayashi KT, Blair RJR, Hubbard NA.   +3 more
europepmc   +2 more sources

Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
Epimer discrimination remains challenging due to subtle NMR differences. Here, we propose a methodology based on 13C‐RCSA and RDC anisotropic parameters, enabling the assignment of two flexible tetraprenyltoluquinol epimers (1a and 1b) with remote stereoclusters.
Juan Carlos C. Fuentes‐Monteverde, Abel M. Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger   +6 more
wiley   +2 more sources

Domesticated bacterial origin genes regulate homeostasis of the insect gut microbiome and empower adaptation

iMeta, EarlyView.
Horizontal gene transfer introduced bacterial CDC genes into the leafhopper genome, providing genetic material for subsequent evolutionary innovation. Different CDC copies diversified at the sequence, structural, and functional levels. RdCDC3 retained its ancestral pore‐forming activity and was recruited for egg defense, whereas RdCDC9 lost its ...
Zhenjia Zhang, Yubo Zhang, Kun Zhao, Guangyuan Cheng, Zhihao Lu, Dongju Wang, Yiqun Liu, Jianguo Wu, Liying Wang, Lisheng Zhang, Xinhai Ye, Li Yu, Wei Zhang, Yi Li   +13 more
wiley   +1 more source

ApoE lipidation state directs immunometabolic reprogramming of human microglia

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION ApoE ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. METHODS Human microglia were treated with lipid‐
Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerem P. Ogbu, Athena A. Schepmoes, Isaac K. Attah, Christy S. Niemeyer, Kayla G. Sprenger, James E. Hassell, Robert H. Eckel, John T. Melchior, Kimberley D. Bruce   +14 more
wiley   +1 more source

Role of Salt Fingering in Recovering the Arabian Sea Oxygen Minimum Zone

Journal of Geophysical Research: Oceans, Volume 131, Issue 9, September 2026.
Abstract Dissolved oxygen (DO) is vital for structuring marine ecosystems and biogeochemistry, making it a sensible indicator of oceanic health. The DO concentration varies spatially, and there are several regional ocean basins characterized by low subsurface oxygen levels.
Abhijit Shee, Bishakhdatta Gayen
wiley   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

One Assay to Rule Them All: Development of a Global Environmental DNA Tool to Support Range‐Wide Surveys of an Imperiled Sawfish and Its Application in the Eastern Tropical Pacific

Ecology and Evolution, Volume 16, Issue 6, June 2026.
To identify promising locations where Largetooth Sawfish, Pristis pristis, may persist, a novel species‐specific Droplet Digital PCR (ddPCR) assay was designed capable of detecting a single copy of DNA, with in silico and in vitro validation experiments indicating functionality across the species' historical range.
Juan C. Cubillos‐M, Annmarie Fearing, Demian D. Chapman, Peter M. Kyne, P. Joana Dias, Cindy Gonzalez, Ryan N. Lehman, Yaliana Chichaco, Bryan L. Huerta‐Beltrán, Kayla L. McCulloch, Sarah M. Toepfer, John K. Carlson, Nicole M. Phillips   +12 more
wiley   +1 more source

Dual‐Site Ru Single‐Atoms and RuP Nanoclusters on N, P, and B Co‐Doped Porous Carbon for Efficient Alkaline HER and AEM Water Electrolysis

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Ru single atoms and RuP nanoclusters are co‐anchored in N, P, and B co‐doped porous carbon nanospheres via in situ carbonization/phosphidation of a boronate polymer precursor. RuP activates water, while nearby Ru single atoms accelerate H2 formation through H* transfer. The catalyst delivers low overpotential and high durability in alkaline HER and AEM
Xiaohong Wang, Juguo Dai, Dongxu Li, Jianghua Wu, Hucheng Fu, Yiting Xu, Xueqiang Qi, Qian Xue, Yanbin Shen, Xiaoqing Pan, Conghui Yuan, Shuifen Xie, Andreu Cabot, Lizong Dai   +13 more
wiley   +1 more source