Results 11 to 20 of about 875 (66)

PLSCR3 Deficiency Triggers mtDNA-Driven cGAS-STING Activation to Potentiate Antitumor Immunity in Colorectal Cancer. [PDF]

Hum Mutat
Background Immunotherapy efficacy in colorectal cancer (CRC) is largely restricted to microsatellite instability‐high (MSI‐H) tumors, highlighting an urgent need to overcome resistance in microsatellite‐stable (MSS) CRC. Mitochondrial DNA (mtDNA) leakage activates the cGAS‐STING pathway, a potent inducer of antitumor immunity.
Ling L, Wu J, Bao L, Liu Z, Deng Q, Ji X, Yu S, Yu F, Zhu A, Xiao Q, Zheng W.   +10 more
europepmc   +2 more sources

Addition of Neuromuscular Electrical Stimulation, Based on the Level of Excitability, to an Intradialytic Twice-Weekly Cycling Protocol: A Randomized Trial. [PDF]

Physiother Res Int
ABSTRACT Background and Purpose Neuromuscular electrical stimulation (NMES) has shown promise as an adjunct or alternative to traditional training, but its optimal application in chronic kidney disease (CKD) population remains uncertain. This study aimed to compare the effects of the NMES intradialytic protocol combined with a traditional cycling on ...
Ferreira BDC, Almeida CNS, Torres DDC, Torres RRS, Durigan JLQ, Carneiro SR, Neves LMT.   +6 more
europepmc   +2 more sources

Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
Epimer discrimination remains challenging due to subtle NMR differences. Here, we propose a methodology based on 13C‐RCSA and RDC anisotropic parameters, enabling the assignment of two flexible tetraprenyltoluquinol epimers (1a and 1b) with remote stereoclusters.
Juan Carlos C. Fuentes‐Monteverde, Abel M. Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger   +6 more
wiley   +2 more sources

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication

Angewandte Chemie International Edition, EarlyView.
Shewanella oneidensis and Bacillus subtilis, both harboring prophages, reveal a novel biosynthetic route to scalable and programmable DNA superstructures in flower‐ and wire‐like shapes, respectively. Activation of prophages is achieved via 3‐hour starvation and monitored using reporter strains.
Gabriel Antonio S. Minero, Line Mørkholt Lund, Lasse Hyldgaard Klausen, Obinna Markraphael Ajunwa, Mingdong Dong, Rikke Louise Meyer, Victoria Birkedal, Kai Thormann   +7 more
wiley   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

One Assay to Rule Them All: Development of a Global Environmental DNA Tool to Support Range‐Wide Surveys of an Imperiled Sawfish and Its Application in the Eastern Tropical Pacific

Ecology and Evolution, Volume 16, Issue 6, June 2026.
To identify promising locations where Largetooth Sawfish, Pristis pristis, may persist, a novel species‐specific Droplet Digital PCR (ddPCR) assay was designed capable of detecting a single copy of DNA, with in silico and in vitro validation experiments indicating functionality across the species' historical range.
Juan C. Cubillos‐M, Annmarie Fearing, Demian D. Chapman, Peter M. Kyne, P. Joana Dias, Cindy Gonzalez, Ryan N. Lehman, Yaliana Chichaco, Bryan L. Huerta‐Beltrán, Kayla L. McCulloch, Sarah M. Toepfer, John K. Carlson, Nicole M. Phillips   +12 more
wiley   +1 more source

Dual‐Site Ru Single‐Atoms and RuP Nanoclusters on N, P, and B Co‐Doped Porous Carbon for Efficient Alkaline HER and AEM Water Electrolysis

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Ru single atoms and RuP nanoclusters are co‐anchored in N, P, and B co‐doped porous carbon nanospheres via in situ carbonization/phosphidation of a boronate polymer precursor. RuP activates water, while nearby Ru single atoms accelerate H2 formation through H* transfer. The catalyst delivers low overpotential and high durability in alkaline HER and AEM
Xiaohong Wang, Juguo Dai, Dongxu Li, Jianghua Wu, Hucheng Fu, Yiting Xu, Xueqiang Qi, Qian Xue, Yanbin Shen, Xiaoqing Pan, Conghui Yuan, Shuifen Xie, Andreu Cabot, Lizong Dai   +13 more
wiley   +1 more source

Essential Role of Icosahedral Symmetry in the 3D Shape of AuAg Plasmonic Nanostars With High Aspect‐Ratio Legs

Small, Volume 22, Issue 27, 14 May 2026.
Electron nanodiffraction mapping was used to determine that the 3D leg configuration of branched plasmonic AuAg nanostars is associated with the icosahedral symmetry of the star core, providing a deeper understanding of their growth mechanism and thus paving the way to the development of optimized synthesis protocols targeting optical enhancement ...
Leonardo M. Corrêa, Simon M. Fairclough, Kaleigh M. R. Scher, Supriya Atta, Diego P. Dos Santos, Caterina Ducati, Laura Fabris, Daniel Ugarte   +7 more
wiley   +1 more source

Ecological restoration hierarchy as a lens to reveal the foundational economic and legal structures impeding restoration

Restoration Ecology, Volume 34, Issue S1, May 2026.
Abstract Introduction Biodiversity loss is accelerating due to habitat destruction, economic expansion, and insufficient conservation efforts. Traditional mitigation strategies, which focus on minimizing harm rather than reversing damage, are inadequate for achieving net biodiversity gain. Objectives This article introduces the restoration hierarchy, a
Niko Soininen, Suvi‐Tuuli Puharinen, Antti Iho, Saija Koljonen, Janne Artell, Kimmo Tolonen, Antti Belinskij   +6 more
wiley   +1 more source