Results 31 to 40 of about 6,973 (108)
Advanced Science, Volume 13, Issue 44, 7 August 2026.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, Volume 13, Issue 47, 24 August 2026.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation
Advanced Science, Volume 13, Issue 43, 3 August 2026.This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar +10 more
wiley +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, Volume 13, Issue 44, 7 August 2026.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal +4 more
wiley +1 more source
oceandatr: An R Package to Acquire and Process Geospatial Ocean Data
Ecology and Evolution, Volume 16, Issue 8, August 2026.We introduce the oceandatr R package, an interface that provides functions for acquiring and processing marine data sources—including bathymetry, geomorphology, ecological, and human use data—and returns these in several grid‐based formats. We outline uses of oceandatr, such as modeling and spatial analysis, and present two case studies where oceandatr
Jason Flower +7 more
wiley +1 more source
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
Cell Proliferation, Volume 59, Issue 8, August 2026.Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song +15 more
wiley +1 more source
Multifactorial nature of anabolic resistance in ageing skeletal muscle: A systems modelling study
The Journal of Physiology, Volume 604, Issue 15, Page 6405-6439, 1 August 2026.Abstract figure legend We leveraged a kinetic model of muscle protein metabolism to investigate the multifactorial drivers of age‐related anabolic resistance. Literature‐derived putative mechanisms of anabolic resistance were integrated into the modelling framework to identify the primary determinants of the blunted postprandial muscle protein ...
Taylor J. McColl +4 more
wiley +1 more source
Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics. [PDF]
Signal Transduct Target TherTang X +21 more
europepmc +1 more source