Results 21 to 30 of about 7,126 (100)

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis [PDF]

Advanced science
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Zhang J, Zhu H, Wang W, Shen B, Xin Y, Song X, Lu X, Li L, Chen S, Zhang X, Zeng J, Zheng H, Lao J, Peng K, Wei Y, Zheng J, Hu C, Wang X, Li X.   +18 more
europepmc   +2 more sources

Multiscale numerical sensitivity simulations of a mesoscale gravity‐wave event

Quarterly Journal of the Royal Meteorological Society, EarlyView.
High‐resolution WRF simulations of the February 14–15, 1992 STORM‐FEST event show that mesoscale gravity‐wave genesis occurs via geostrophic adjustment within an upper‐level unbalanced jet, while wave ducting governs maintenance. High‐resolution (1 km), improved physical parameterization, and targeted sensitivity simulations demonstrate that upstream ...
Rajan Bhandari, Michael L. Kaplan, Ananya Sen   +2 more
wiley   +1 more source

Responsive nanoheterojunctions for built‐in electric field‐promoted cascade tumor targeting and cuproptosis‐based therapy

Responsive Materials, EarlyView.
Nanoheterojunctions have been synthesized as responsive biomaterials for cascade targeting of tumor cells and mitochondria, ROS‐mediated apoptosis and Cu‐promoted cuproptosis. And drug‐device‐field integration as an advanced paradigm of tumor treatment was employed for photo‐triggered tumor cell elimination in vitro and lesion eradication in vivo ...
Zhe Liu, Yandai Lin, Xuehui Li, Fengqi Xuan   +3 more
wiley   +1 more source

Consistent Choice of Prey Source Habitat Across Diverse Landscapes by a Selective Insectivorous Bat

Integrative Zoology, EarlyView.
After analyzing the diet of the greater horseshoe bats in three distinct colonies, we identified significant spatial and temporal differences, particularly noting a stronger reliance on riparian habitats in Mediterranean areas. The species exhibits great ecological adaptability with strong plasticity in prey source habitats, shifting preferences among ...
Miren Aldasoro, Oihane Diaz de Cerio, Danilo Russo, Nerea Vallejo, Lander Olasagasti, Inazio Garin, Urtzi Goiti, Joxerra Aihartza   +7 more
wiley   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Journal of Anatomy, EarlyView.
To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima, Noe Kaneko, Ayumu Morioka, Anna Hoerder‐Suabedissen, Zoltán Molnár, Chiaki Ohtaka‐Maruyama   +8 more
wiley   +1 more source

Preparation and characterization of PLGA Nanoparticles containing recombinant core-NS3 Fusion protein of hepatitis C virus as a nano-vaccine candidate

Vaccine Research, 2017
Introduction: Hepatitis C virus (HCV) is one of the most serious causes of cirrhosis, liver cancer and ultimately death, worldwide. The new direct-acting drugs are not accessible for many patients around the world and progress toward new therapeutic and ...
S Hekmat, MM Aslani, M Shafiee Ardestani, MR Aghasadeghi, SD Siadat, SM Sadat, M Mahdavi, S Shahbazi, F Asgarhalvaee, SMM Ghahari, F Tohidi   +10 more
doaj  

ApoE lipidation state directs immunometabolic reprogramming of human microglia

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION ApoE ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. METHODS Human microglia were treated with lipid‐
Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerem P. Ogbu, Athena A. Schepmoes, Isaac K. Attah, Christy S. Niemeyer, Kayla G. Sprenger, James E. Hassell, Robert H. Eckel, John T. Melchior, Kimberley D. Bruce   +14 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, Volume 293, Issue 20, Page 6230-6252, October 2026.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Breaking Out of Low‐Effort Traps: Bureaucratic Leadership by Persuasion

Governance, Volume 39, Issue 4, December 2026.
ABSTRACT This paper tests if bureaucratic leadership impacts the quality of service provision of a difficult‐to‐monitor task: learning in public schools. Using the empirical case of rural India, it exploits an administrative setup with two types of bureaucrats for the same spatial unit, the district, that either have more authority or more ability to ...
Martin Haus
wiley   +1 more source