Results 61 to 70 of about 36,837 (275)

Hexachlorocyclohexane and DDT in marine organisms from the Bering and the Okhotsk Seas

Известия ТИНРО, 2014
Organochlorine pesticides (HCHs and DDT) are harmful and toxic substances affected biota. HCHs and DDT are still used as pesticides in the Southern Hemisphere and from there can reach the North Pacific due to atmospheric transfer.
Vasily Yu. Tsygankov, Margarita D. Boyarova, Olga N. Lukyanova, Nadezhda K. Khristoforova   +3 more
doaj   +1 more source

Design and Synthesis of Boron‐Containing Noncanonical Amino Acids With Enhanced Stability and Solubility

European Journal of Organic Chemistry, EarlyView.
We report a new class of boron‐containing noncanonical amino acids with improved aqueous solubility and stability. Structural tuning around the boron center enhances biological compatibility, and unique fluorescence properties suggest applications in protein engineering and biosensing, advancing boron‐based tools for chemical biology and drug discovery.
Eunsol Jo, Hyojung Ahn, Guldana Issabayeva, On‐Yu Kang, Jungtaek Kim, Young‐Chul Song, Ik Jae Lee, Hei‐Cheul Jeung, Ji Young Hyun, Seong Jun Park, Hwan Jung Lim   +10 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Tribal preventive practices toward malaria in East Godavari District, Andhra Pradesh

Journal of Dr. NTR University of Health Sciences
Introduction: Malaria is one of the world’s important parasitic diseases. Malaria deaths reached 445,000 in 2016, a similar number (446,000) to 2015. In 2017, India contributed to 633,481 malaria cases and 103 deaths due to malaria.
G Krishnababu, G. Sravana Kumar, MC Amaranath Reddy, K. Sowmyasudha   +3 more
doaj   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Global trends in the production and use of DDT for control of malaria and other vector-borne diseases

Malaria Journal, 2017
Background DDT was among the initial persistent organic pollutants listed under the Stockholm Convention and continues to be used for control of malaria and other vector-borne diseases in accordance with its provisions on acceptable purposes.
Henk van den Berg, Gamini Manuweera, Flemming Konradsen   +2 more
doaj   +1 more source

Next‐Generation Biosensors for Real‐Time Quality Monitoring in the Food Industry

Food Bioengineering, EarlyView.
This graphical abstract highlights the use of biosensors for real‐time monitoring of food quality and safety across grains, dairy, meat, seafood, fruits, beverages, bakery, and packaging. Central to this is signal processing, enabling rapid, accurate detection of contaminants, spoilage, and adulterants from farm to fork.
Drisya Raj M. P., Roopa Shri B., Chinta Suneetha, Kanimozhi N.V., Sonali L., Pavithra R., Ashok Kumar S., Palpandi Raja R., Sukumar M.   +8 more
wiley   +1 more source

Nonmalarial Infant Deaths and DDT Use for Malaria Control

Emerging Infectious Diseases, 2003
Although dichlorodiphenyl trichloroethane (DDT) is being banned worldwide, countries in sub-Saharan Africa have sought exemptions for malaria control. Few studies show illness in children from the use of DDT, and the possibility of risks to them from DDT
Aimin Chen, Walter J. Rogan
doaj   +1 more source