Results 51 to 60 of about 180,404 (254)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

De face et de profil

open access: yesActa Fabula, 2005
Cet article est un compte-rendu du livre : Denis Guénoun, Actions et acteurs.
openaire   +1 more source

Métodos Estatísticos no Reconhecimento de Faces

open access: yesRevista Eletrônica de Sistemas de Informação, 2006
Estuda-se o reconhecimento de faces usando métodos estatísticos clássicos do entudo de reconhecimento da padrões. Ilustrando a metodologia são apresentados exemplos concretos de sucesso e insucesso.
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Enfrentamento de problemas conceituais e de planejamento ao final da formação inicial Facing conceptual and planning problems at the end of initial training

open access: yesCiência & Educação, 2010
Apresentase uma reflexão sobre o processo de enfrentamento de problemas por futuros professores de Física, no período de estágio supervisionado, a partir de modelos construídos numa pesquisa desenvolvida junto a um grupo de professores em formação ...
Sandro Rogério Vargas Ustra   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

'Sensory analysis of specialty coffee from different environmental conditions in the region of Matas de Minas, Minas Gerais, Brazil

open access: yesRevista Ceres
Specialty coffees can be differentiated in various ways, including the environmental conditions in which they are produced and the sensory composition of the drink.
Alice de Souza Silveira   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Universidades Interculturales en México

open access: yesCPU-e, 2014
El presente artículo ofrece una visión panorámica de un nuevo tipo de institución de educación superior: las universidades interculturales. Partiendo de una breve contextualización de sus orígenes en el entorno post-zapatista mexicano, se ofrece una ...
Dr. Gunther Dietz
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

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