Results 11 to 20 of about 784,112 (127)
Wellcome Open Research, 2021 Background: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease caused by mutations in the dystrophin gene. Due to their phenotypic similarity to human patients, large animal models are invaluable tools for pre-clinical trials.
John C. W. Hildyard +4 more
doaj +2 more sources
Identification of reference microRNAs in skeletal muscle of a canine model of Duchenne muscular dystrophy [version 2; peer review: 2 approved] [PDF]
Wellcome Open ResearchBackground Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease caused by mutations in the dystrophin gene. DE50-MD dogs are an animal model of DMD used as a final translational model for evaluation of promising treatments.
Richard J. Piercy +4 more
doaj +2 more sources
The preclinical cardiac phenotype of the DE50-MD dog model of Duchenne muscular dystrophy
Abstract Cardiomyopathy is the leading cause of death in the X-linked disorder, Duchenne Muscular Dystrophy (DMD) yet optimal management strategies remain undetermined. Advances in the search for novel DMD treatments, particularly at cell and molecular levels, rely heavily on the use of translational animal models.
Sargent J +6 more
europepmc +2 more sources
Abstract Cardiomyopathy is an expected consequence of the invariably fatal, X-linked muscle-wasting disease, Duchenne Muscular Dystrophy, (DMD) but onset and progression vary between individuals. Cardiac magnetic resonance imaging (CMR) is invaluable for identification of subclinical myocardial abnormalities, to stratify disease and to ...
Sargent J +6 more
europepmc +2 more sources
Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13-cis-Retinoic Acid is a PTP1B Inhibitor. [PDF]
ChemMedChemA computational screening using cheminformatics and molecular docking has been performed on PTP1B. In vitro assays have revealed that 13‐cis‐retinoic acid is a competitive inhibitor. This is the first report of 13‐cis‐retinoic acid as PTP1B inhibitor, making it a valuable candidate for future research toward its repositioning.
Del Carmen Navarrete-Mondragón R +4 more
europepmc +2 more sources
Unveiling environmental justice through open government data: Work in progress for most US states
Public Administration, Volume 101, Issue 3, Page 1088-1114, September 2023., 2023 Abstract Open government data (OGD) are critical for environmental justice (EJ) policymaking, which is characterized by power and information asymmetries across government agencies, affected populations, and advocacy groups. We contend that not only should state governments provide OGD but also they should remove the burden associated with data access ...
Federica Fusi +2 more
wiley +1 more source
Regional Science Policy &Practice, Volume 15, Issue 3, Page 559-584, April 2023., 2023 Abstract We identify vulnerable groups through the examination of their employment status in the face of the initial coronavirus disease 2019 (COVID‐19) shock through the application of tree‐based ensemble machine learning algorithms on a sample of individuals over 50 years old. The present study elaborates on the findings through various interpretable
Mehmet Güney Celbiş +3 more
wiley +1 more source
Maternal mental health and infant neurodevelopment at 6 months in a low‐income South African cohort
Infant Mental Health Journal: Infancy and Early Childhood, Volume 43, Issue 6, Page 849-863, November 2022., 2022 Abstract Maternal mental health disorders and the adverse consequences for infant neurodevelopment have received substantial research attention in high‐income countries over the past five decades. In Africa, where relatively little work has been done on this topic, researchers have largely focused on infant physical health outcomes.
Marlette Burger +4 more
wiley +1 more source
Browsing for food: Will COVID‐induced online grocery delivery persist?
Regional Science Policy &Practice, Volume 14, Issue S1, Page 179-195, November 2022., 2022 Abstract The COVID‐19 pandemic altered daily activities. Many consumers reverted to online grocery shopping and home delivery. We analyze factors associated with the decision to grocery shop online and whether this will persist post‐COVID using data collected via a representative online Qualtrics panel in the State of New Jersey (N = 1,419).
Hannah Younes +2 more
wiley +1 more source
Infant Mental Health Journal: Infancy and Early Childhood, Volume 42, Issue 1, Page 109-123, January/February 2021., 2021 ABSTRACT Randomized controlled trials (RCTs) demonstrate efficacy of parent–infant psychotherapy, but its applicability and effectiveness in public health care are less known. The method followed is Naturalistic study evaluating Short‐term Psychodynamic Infant–Parent Interventions at Child Health Centers (SPIPIC) in Stockholm, Sweden.
Björn Salomonsson +4 more
wiley +1 more source