Results 11 to 20 of about 785 (140)

Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy. [PDF]

Neuromuscul Disord, 2021
The DE50-MD canine model of Duchenne muscular dystrophy (DMD) has a dystrophin gene splice site mutation causing deletion of exon 50, an out-of-frame transcript and absence of dystrophin expression in striated muscles. We hypothesized that the musculoskeletal phenotype of DE50-MD dogs could be detected using Magnetic Resonance Imaging (MRI), that it ...
Hornby NL, Drees R, Harron R, Chang R, Wells DJ, Piercy RJ.   +5 more
europepmc   +5 more sources

Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy [version 1; peer review: 2 approved]

Wellcome Open Research, 2021
Background: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease caused by mutations in the dystrophin gene. Due to their phenotypic similarity to human patients, large animal models are invaluable tools for pre-clinical trials.
John C. W. Hildyard, Dominic J. Wells, Rachel C. M. Harron, Dominique O. Riddell, Richard J. Piercy   +4 more
doaj   +2 more sources

Avaliação da eficácia do antiveneno botrópico administrado no local da inoculação intramuscular do veneno de Bothrops jararaca: estudo experimental em camundongos Assessment of the efficacy of antivenom injection at the site of the intramuscular inoculation of Bothrops jararaca venom in mice

Revista do Instituto de Medicina Tropical de São Paulo, 1994
Foi determinada, em camundongos de 18 a 20 g, a dose efetiva 50% do antiveneno botrópico, por via intraperitoneal (ip), imediatamente (DE50 Oh) e 30 minutos (DE50 30') após a inoculação de 2 DL50 do veneno de B. jararaca, por via intramuscular (im).
Carla Lilian Agostini Utescher, Silvia Lucia Paro Vieira, Sara Fensterseifer, Liodioneza Adriano Ribeiro, Miguel Tanús Jorge   +4 more
doaj   +2 more sources

Identification of quantitative polymerase chain reaction reference genes suitable for normalising gene expression in the brain of normal and dystrophic mice and dogs [version 2; peer review: 2 approved, 1 approved with reservations] [PDF]

Wellcome Open Research, 2023
Background: In addition to progressive, debilitating muscle degeneration, ~50% of patients with Duchenne muscular dystrophy (DMD) have associated cognitive and behavioural disorders secondary to deficiency of dystrophin protein in the brain.
Abbe H. Crawford, Dominic J. Wells, John C. W. Hildyard, Richard J. Piercy   +3 more
doaj   +2 more sources

Sensibilidade de isolados de Septoria lycopersici e eficácia de fungicidas no controle de septoriose em tomateiro [PDF]

Revista de Ciências Agroveterinárias, 2020
A septoriose é uma das principais doenças do tomateiro e os prejuízos causados variam em função da área cultivada com cultivar suscetível, raças fisiológicas do patógeno e condições climáticas.
Alana Karine Baldicera, Amauri Bogo, Francine Regianini Nerbass, Walter Ferreira Becker, Ricardo Trezzi Casa, Fábio Nascimento da Silva   +5 more
doaj   +2 more sources

The preclinical cardiac phenotype of the DE50-MD dog model of Duchenne muscular dystrophy

Abstract Cardiomyopathy is the leading cause of death in the X-linked disorder, Duchenne Muscular Dystrophy (DMD) yet optimal management strategies remain undetermined. Advances in the search for novel DMD treatments, particularly at cell and molecular levels, rely heavily on the use of translational animal models.
Sargent J, Fuentes VL, Terry R, Riddell DO, Harron RC, Wells DJ, Piercy RJ.   +6 more
europepmc   +2 more sources

Underlying data - DE50-MD blood biomarker – MYOM3 WB TIFFs - Riddell, Hildyard, Harron, Wells, Piercy.

, 2021
This folder contains all raw MYOM3 western blot images for the manuscript: Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy.
Richard Piercy (10213257), John Hildyard (2556154), Dominique Riddell (11717924), Rachel Harron (11717940), Dominic Wells (10213256)   +4 more
core   +1 more source

Raw data: DE50-MD Serum inflammatory cytokines - Riddell Hildyard Harron Hornby Wells Piercy

, 2021
Folder contains raw data for Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy • Luminex raw data • Correlation between serum CCL2 and other biomarkers of DE50-MD Serum CCL2 vs plasma CK ...
Richard Piercy (10213257), John Hildyard (2556154), Dominique Riddell (11717924), Rachel Harron (11717940), Dominic Wells (10213256)   +4 more
core   +1 more source

Sensibilidad in vitro de tres agentes fúngicos en Rubus glaucus Benth y cuatro agentes fúngicos en Opuntia ficus indica L. a fungicidas de diferentes modos de acción. [PDF]

, 2022
El objetivo del presente trabajo de investigación fue determinar la sensibilidad in vitro a Fusarium oxysporum, Fusarium redolens, Fusarium solani en Rubus glaucus Benth, y los géneros Geotrichum sp., Alternaria sp., Fusarium sp., Epicoccum sp.
Melena Gunsha, Sandy Belén
core   +1 more source

Extended data - DE50-MD blood biomarker - Riddell, Hildyard, Harron, Wells, Piercy.

, 2021
Folder contains extended data for Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy • Early vs late euthanasia raw data• Early vs late euthanasia ...
Richard Piercy (10213257), John Hildyard (2556154), Dominique Riddell (11717924), Rachel Harron (11717940), Dominic Wells (10213256)   +4 more
core   +1 more source