Results 241 to 250 of about 2,481,224 (301)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Atomically accurate de novo design of antibodies with RFdiffusion. [PDF]

Nature
Bennett NR, Watson JL, Ragotte RJ, Borst AJ, See DL, Weidle C, Biswas R, Yu Y, Shrock EL, Ault R, Leung PJY, Huang B, Goreshnik I, Tam J, Carr KD, Singer B, Criswell C, Wicky BIM, Vafeados D, Garcia Sanchez M, Kim HM, Vázquez Torres S, Chan S, Sun SM, Spear TT, Sun Y, O'Reilly K, Maris JM, Sgourakis NG, Melnyk RA, Liu CC, Baker D.   +31 more
europepmc   +1 more source

Climate Action Impacts on Steelmaking Emissions of Persistent Organic Pollutants Highlight a Gap Between the Paris Agreement and the Stockholm Convention

Advanced Science, EarlyView.
Emissions of unintentionally produced persistent organic pollutants (UPOPs) and global warming are two major environmental challenges. But their governance has largely evolved in parallel, leaving the toxicity implications of climate‐driven industrial transitions poorly understood.
Yuxiang Sun, Qiuting Yang, Jianghui Yun, Yujue Yang, Junhao Tang, Qian Liu, Minghui Zheng, Guorui Liu   +7 more
wiley   +1 more source

Clinical and genetic insights into novel TP53 mutations in De Novo AML patients. [PDF]

Clin Exp Med
Akram AM, Hayat S, Yousaf H, Sarwar N, Tahir A, Ali S, Yaqoob F, Zafar A, Hassan HM, Dabiellil M, Khan MIU.   +10 more
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Germline de novo mutation rate of the highly heterozygous amphioxus genome. [PDF]

Mol Biol Evol
Xue J, Tao L, Cao J, Wu L, Li G, Li C.
europepmc   +1 more source

Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast. [PDF]

EMBO Rep
Tawfeeq MT, Konstantinidis D, Rocha Iraizos AL, Van Genechten W, Vreys J, Vermeersch L, Voordeckers K, Van Dijck P, Verstrepen KJ.   +8 more
europepmc   +1 more source

Author Correction: Complex de novo structural variants are an underestimated cause of rare disorders. [PDF]

Nat Commun
Jung H, Yang TP, Walker S, Danecek P, Garcia-Salinas OI, Neville MDC, Christopher J, Cortés-Ciriano I, Firth H, Scally A, Hurles M, Campbell P, Rahbari R.   +12 more
europepmc   +1 more source