Results 41 to 50 of about 563,940 (260)
Electrodialysis (ED) has already been applied to recover nickel in galvanizing processes, allowing nickel recovery and the production of a treated effluent with demineralized water quality. However, the growth in ED use is still limited by the production
Fabrício Wilbert +7 more
doaj +1 more source
Renal cell cancer (RCC) in renal allograft is a rare entity. We report a case of RCC successfully diagnosed in a 42-year-old renal allograft recipient which developed 13 years after engraftment.
Shashank Agrawal +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BackgroundAdjuvant radiotherapy (RT) is one of the most commonly used treatments for de novo high-grade meningiomas (HGMs) after surgery, but genetic determinants of clinical benefit are poorly characterized.ObjectiveWe describe efforts to integrate ...
Jiaojiao Deng +23 more
doaj +1 more source
Novos petroglifos de Rego Novo (Amoedo- Pazos de Borbén)
Este artigo resume os resultados dunha prospección arqueolóxica realizada en certas zonas do concello de Pazos de Borbén (Pontevedra- Galicia) seleccionadas pola presenza de Arte Rupestre. Preséntanse os petroglifos achados nesta zona e faise unha breve análise de conxunto que se fixa na distribución e emprazamento dos mesmos, advertindo da súa ...
openaire +5 more sources
The ultimate goal in protein de novo design is the construction of artificial proteins exhibiting tailor-made structural and functional properties. To create native-like macromolecules in copying nature's way has proven to be difficult because the mechanism of folding in its complexity has yet to be unraveled.
Tuchscherer, Gabriele +2 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Background: Low-pass genome sequencing (GS) detects clinically significant copy number variants (CNVs) in prenatal diagnosis. However, detection at improved resolutions leads to an increase in the number of CNVs identified, increasing the difficulty of ...
Matthew Hoi Kin Chau +23 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
De novo vasculogenesis in the heart [PDF]
The formation of the embryonic heart vasculature is a complex process and is the result of vasculogenic, angiogenic and arteriogenic mechanisms, involving cells from distinct origins. In the neonate and the adult, several sources of endothelial precursor cells (EPCs) have been identified that contribute to physiological and pathological vascularization,
Aernout, Luttun, Peter, Carmeliet
openaire +2 more sources

