Results 61 to 70 of about 563,940 (260)

Nonisomorphic and nonisotopic multidermatomal discoid lupus erythematosus – A rare subtype of cutaneous lupus erythematosus

Indian Dermatology Online Journal, 2020
Discoid lupus erythematosus (DLE) is the most common variant of chronic cutaneous lupus erythematosus. Several cases of Blaschko-linear lupus erythematosus, which is regarded as a distinct subtype of lupus erythematosus, have been reported across the ...
Sanjiv Choudhary, Ankita Srivastava, Mukesh Sahni, Santosh Tummudi   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Individualização Farmacocinética das Doses de 5-Fluoruracil no Câncer Colorretal

Revista Brasileira de Cancerologia, 2013
Introdução: O 5-Fluoruracil (5-FU) é um antimetabólito amplamente utilizado no tratamento do câncer colorretal, com significativa variabilidade na resposta terapêutica e na ocorrência de toxicidade associada à sua farmacocinética variável.
Carina Gomes Martins, Sandrine Comparsi Wagner, Rafael Linden   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Modelagem e otimização da codigestão anaeróbia de resíduos da suinocultura e mandioca

Revista Principia
O crescimento das cadeias produtivas da suinocultura e da agroindústria de processamento da mandioca intensifica a geração de resíduos líquidos com elevado potencial poluidor.
José Domingos de Melo Neto, Vera Lúcia Fülber Domingos de Melo, Leandro Fleck   +2 more
doaj   +1 more source

Genotoxic Potential and Physicochemical Parameters of Sinos River, Southern Brazil

The Scientific World Journal, 2013
The present study aimed to evaluate the physicochemical parameters and the genotoxic potential of water samples collected in the upper, middle, and lower courses of the Sinos River, southern Brazil.
Madalena C. S. Scalon, Ciliana Rechenmacher, Anna Maria Siebel, Michele L. Kayser, Manoela T. Rodrigues, Sharbel W. Maluf, Marco Antonio S. Rodrigues, Luciano Basso da Silva   +7 more
doaj   +1 more source

Modelagem matemática do tratamento de efluente de sangue animal por eletrofloculação [PDF]

Revista DAE
O processamento de sangue animal gera efluentes líquidos. Como alternativa aos tratamentos convencionais, cita-se a técnica de eletrofloculação. Este estudo avalia a eficácia do tratamento eletroquímico de efluentes do processamento de sangue animal e ...
Andrieli Sena Lacerda, Larissa Augusta da Cruz, Izabel Melz Fleck, Leandro Fleck   +3 more
doaj   +1 more source