Results 131 to 140 of about 4,559 (313)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

On energy–momentum tensor for gravitational waves in f(R) gravity

European Physical Journal C: Particles and Fields
The classical Isaacson’s procedure for describing back-reaction of the averaged energy–momentum for high frequency gravitational waves is generalized to the f(R) gravity case. From the beginning it is assumed that an initial background could be arbitrary
Petr V. Tretyakov, Alexander N. Petrov
doaj   +1 more source

Loops in anti de Sitter space

Journal of High Energy Physics
Abstract We discuss general one and two-loop banana diagrams and one-loop diagrams with external lines with arbitrary masses on the anti de Sitter spacetime by using methods of AdS quantum field theory in the dimensional regularization approach.
Sergio L. Cacciatori, Henri Epstein, Ugo Moschella   +2 more
openaire   +4 more sources

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

De Sitter entropy: On-shell versus off-shell

Physics Letters B
Attributing thermodynamic properties to the Bunch-Davies state in static patch of de Sitter space and setting the corresponding equations of state, we demonstrate that, for pure gravity, the bulk entropy – computed on-shell as a volume integral in de ...
D.V. Diakonov
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Information conservation in de Sitter tunneling

European Physical Journal C: Particles and Fields
In this paper, we consider the three most general cases of progressive de Sitter spacetime. The charged and magnetic particles tunnel into the magnetically charged Reissner–Nordström de Sitter black hole (the most general case of a static black hole ...
Baoyu Tan
doaj   +1 more source

Entanglement entropy of α-vacua in de Sitter space [PDF]

, 2014
Sugumi Kanno, Jeff Murugan, Jonathan P. Shock, Jiro Soda   +3 more
openalex   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Quantum Cramer–Rao Bound for a Massless Scalar Field in de Sitter Space [PDF]

, 2017
Marcello Rotondo, Yasusada Nambu
openalex   +1 more source