Results 121 to 130 of about 60,692 (275)

Lost at Sea: Introduction to Numerical Methods through Navigation

open access: yes, 2019
Excerpt: The ship, El Perdido, was damaged during a storm which knocked out its main and backup power generators. Before the backup generator failed, Captain Miguel Gomez sent a distress call and the crew have been able to keep El Perdido a oat, but the
Harwood, R. Corban
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Lunar navigation study, volume 2 Final report, Jan. - Dec. 1966 [PDF]

open access: yes
Performance data utilization in mission phase, lunar exploration phase, and navigational phase of lunar roving vehicle ...
Broadbent, J. T.   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Using dead-reckoning to track movements and map burrows of fossorial species

open access: yesAnimal Biotelemetry
Background Researching the movement patterns of fossorial animals and mapping of burrow systems presents a significant challenge due to the difficulty of direct observation and the limitations of most tracking systems to collect location fixes ...
James Redcliffe   +5 more
doaj   +1 more source

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