Results 51 to 60 of about 2,131 (306)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Learning from Outside the Viability Kernel: Why we Should Build Robots that can Fall with Grace

, 2018
Despite impressive results using reinforcement learning to solve complex problems from scratch, in robotics this has still been largely limited to model-based learning with very informative reward functions. One of the major challenges is that the reward
Heim, Steve, Spröwitz, Alexander
core   +1 more source

Control of a Modular Multi-level Converter STATCOM for Low Voltage Ride-Through Condition [PDF]

, 2016
This paper presents a simulation study on the implementation of the Single Star Flying Capacitor Converter Modular Multi-level Cascaded Converter (MMCC-SSFCC) as a STATCOM operating under voltage sag condition.
Oghorada, OJK, Zhang, L
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Current Control for Synchronous Motor Drives: Direct Discrete-Time Pole-Placement Design [PDF]

, 2015
This paper deals with discrete-time models and current control methods for synchronous motors with a magnetically salient rotor structure, such as interior permanent-magnet synchronous motors and synchronous reluctance motors (SyRMs).
Awan, Hafiz, Briz, Fernando, Hinkkanen, Marko, Qu, Zengcai, Tuovinen, Toni   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Robust predictive current control of permanent magnet synchronous motor using voltage coefficient matrix update

International Journal of Electrical Power & Energy Systems
In this study, a novel robust deadbeat predictive current control algorithm using voltage coefficient matrix update (DPCC-VCMU) is proposed for permanent magnet synchronous motor (PMSM), which can eliminate the influence of model parameter mismatch ...
Jing He, Runzhong Tang, Qiuwei Wu, Changfan Zhang, Gongping Wu, Shoudao Huang   +5 more
doaj   +1 more source

Simple and robust predictive direct control of DFIG with low constant switching frequency and reduced torque and flux ripples [PDF]

, 2011
For conventional direct torque control (CDTC) methods, there are usually undesired torque and flux ripples mainly for two reasons. First, the vectors selected are not necessary the best. Secondly, one-step delay influence in digital implementation causes
Guo, Y, Hu, J, Ma, Q, Zhang, Y, Zhu, J
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source