Results 81 to 90 of about 40,363 (219)

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

Effectiveness of Over‐the‐Counter Hearing Aids Versus Professionally Fitted Devices: A Systematic Review and Meta‐analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To systematically review and meta‐analyze the clinical effectiveness of self‐fitting over‐the‐counter (OTC) hearing aids compared with professionally fitted devices. Data Sources PubMed, Scopus, Web of Science, Food and Drug Administration (FDA) 510(k) and De Novo databases, and ClinicalTrials.gov were searched in March 2025 and ...
Karina C. De Sousa, Ibrahim Almufarrij, Megan Kruger, Vinaya Manchaiah, Kevin J. Munro, De Wet Swanepoel   +5 more
wiley   +1 more source

Exploring adult education and career opportunities for people with disabilities

Fogyatékosság és Társadalom
The study examines the current issues concerning equal opportunity access for People with disabilities from the perspective of Hungarian vocational and adult education.
Hangya, Dóra
doaj   +1 more source

Characterizing Music Engagement and Reward in Individuals Across a Spectrum of Hearing Loss and Rehabilitation

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Hearing aids (HAs) and cochlear implants (CIs) improve speech perception for individuals with hearing loss (HL), yet their impact on music outcomes remains unclear. We examined music perception, engagement, and reward in a large cohort of individuals across various hearing conditions. Study design Cross‐sectional survey.
Emily Gao, Maria Armache, Joon Soo Kim, Celine Arar, Elaine C. Thompson, Claire Wang, Marshall Chasin, Theodore R. McRackan, Alexander Chern   +8 more
wiley   +1 more source

CHARGE Syndrome: What an Otolaryngologist Should Know—A Systematic Review and Meta‐Analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To synthesize the prevalence of otolaryngologic manifestations in CHARGE syndrome (CS) to support otolaryngologists in delivering comprehensive management. Data Sources PubMed/MEDLINE, Embase, and Google Scholar were searched for English‐ and French‐language studies published from January 1980 through January 2025.
Camille Caron, Massil Badji, Camille Prigent, Alix Pincivy, Erika Mercier, Mathieu Bergeron   +5 more
wiley   +1 more source

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski, H. Jeffrey Kim, Carmen C. Brewer, Sophia Martinez, Caroline Rieger, Elena Cho, David H. McDermott, Philip M. Murphy   +7 more
wiley   +1 more source

Regenerative Injection Laryngoplasty With Scaffold‐Forming Oligomer and Autologous Motor Endplate‐Expressing Cells: A 6‐Month Porcine Study

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Injection laryngoplasty is a standard‐of‐care intervention for unilateral vocal fold paralysis (UVFP), offering minimally invasive medialization with limited durability. We evaluated a regenerative injectable approach integrating an immunotolerant scaffold‐forming collagen (Oligomer) with autologous motor‐endplate expressing (MEE ...
Gabriel G. Sobczak, Rachel A. Morrison, Lujuan Zhang, Patrick R. Finnegan, Benjamin Johnson, Eric Dong, Bailey Egan, Aditya Bhatt, Sherry L. Voytik‐Harbin, Stacey Halum   +9 more
wiley   +1 more source

Aquisição de advérbios não manuais em HKSL por crianças surdas no Jockey Club Sign Bilingualism and Co-enrolment in Deaf Education Programme

Cadernos de Saúde, 2013
Jia Li, Scholastica Lam, Cat H.-M. Fung
doaj   +1 more source

Effects of Minority Status on Sensory Outcomes, Cognition, and Depression

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the association between minority status and sensory function, sleep quality, depressive symptoms, and cognitive performance in an aging population. Study Design Prospective, cross‐sectional study. Setting Participants were recruited from the Department of Otolaryngology and the Center for Cognitive Neuroscience and Aging ...
Ivette Cejas, Jennifer Coto, Aria Nawab, Alberto Cruz, Sandra Velandia, Pawan Pathagamage, Molly Smeal, Rosie C. Cid, David Loewenstein, Xue Z. Liu   +9 more
wiley   +1 more source