Results 91 to 100 of about 232,677 (345)

Rescue of hearing and vestibular function in a mouse model of human deafness

Nature Medicine, 2013
Hearing impairment is the most common sensory disorder, with congenital hearing impairment present in approximately 1 in 1,000 newborns. Hereditary deafness is often mediated by the improper development or degeneration of cochlear hair cells.
J. Lentz, Francine M. Jodelka, A. Hinrich, Kate E. McCaffrey, H. Farris, Mathew J. Spalitta, N. Bazan, D. Duelli, F. Rigo, M. Hastings   +9 more
semanticscholar   +1 more source

MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

Developmental Dynamics, EarlyView.
Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister, Keisuke Sugiwaka, Tetsuaki Kimura, Rieko Tanaka, Makoto Goda, Hikaru Kobayashi, Chikako Inoue, Kawilarang W. A. Masengi, Kazunori Yamahira, Kiyoshi Naruse, Satoshi Ansai, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto   +13 more
wiley   +1 more source

The acoustic change complex as a diagnostic tool for cochlear dead regions evaluated in normally hearing adults

Scientific Reports
The loss of inner hair cells and/or neurons in the cochlea leads to cochlear dead regions (DRs). One of the consequences of DRs is noisy transmission of information from the cochlea to the brain, which results in poorer than expected perception of speech
Anna Schelenz, Emanuele Perugia, Lin Wu, Ewa Skrodzka, Karolina Kluk   +4 more
doaj   +1 more source

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Cell Reports, 2015
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET ...
Kiyoto Kurima, Seham Ebrahim, Bifeng Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshiyuki Kawashima, Byung Yoon Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar   +14 more
doaj   +1 more source

Synergistic Microstructure and Dielectric Engineering of Recyclable Single‐Electrode Triboelectric Nanogenerators for Sustainable Smart Homes

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A recyclable triboelectric nanogenerator integrating a pseudo‐honeycomb microstructure with liquid metal doping achieves 120% higher output (122 mW m−2) and >90% retention over seven cycles, enabling self‐powered smart home functions. The performance of single‐electrode triboelectric nanogenerators (SE‐TENGs) is governed by the effective contact area ...
Chencheng Hu, Yuehan Pei, Wenbo Hu, Yu Qi, Ruida Cao, Long Yang, Zitong Kan, Yang Lu, Biao Dong, Hongwei Song, Lin Xu   +10 more
wiley   +1 more source

Clinical efficacy of mepolizumab and dupilumab for eosinophilic otitis media: Analysis of patient clinical characteristic

Allergology International
Background: Eosinophilic otitis media (EOM) is characterized by eosinophilic infiltration of the middle ear; it is frequently associated with bronchial asthma and chronic rhinosinusitis with nasal polyposis. Although biologics have been used to treat EOM,
Saori Kikuchi, Tomonori Sugiyama, Saemi Suzuki, Yukiko Iino   +3 more
doaj   +1 more source

CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer

Neoplasia: An International Journal for Oncology Research, 2014
Cancer stem cells (CSC) and genes have been linked to cancer development and therapeutic resistance, but the signaling mechanisms regulating CSC genes and phenotype are incompletely understood. CK2 has emerged as a key signal serine/threonine kinase that
Hai Lu, Carol Yan, Xin Xin Quan, Xinping Yang, Jialing Zhang, Yansong Bian, Zhong Chen, Carter Van Waes   +7 more
doaj   +1 more source

Targeted Exon Sequencing Successfully Discovers Rare Causative Genes and Clarifies the Molecular Epidemiology of Japanese Deafness Patients

PLoS ONE, 2013
Target exon resequencing using Massively Parallel DNA Sequencing (MPS) is a new powerful strategy to discover causative genes in rare Mendelian disorders such as deafness.
Maiko Miyagawa, Takehiko Naito, S. Nishio, N. Kamatani, S. Usami   +4 more
semanticscholar   +1 more source

Occupational deafness: helping farmers to fence off excessive noise

, 2001
This paper is a summary of a conference paper presented earlier in South Africa. It presents results of testing for industrial deafness amongst Australian farmers.
Eddington, Ian
core   +1 more source

Heritability and complex segregation analysis of deafness in Jack Russell Terriers

BMC Veterinary Research, 2007
Background The association between patterns of pigmentation and deafness in the dog has a long-documented history, with reports dating back over one hundred years.
Strain George M, Cargill Edward J, Famula Thomas R   +2 more
doaj   +1 more source