Results 61 to 70 of about 53,995 (223)

Clinical Features and Influencing Factors for the Prognosis of Patients With Sudden Deafness

Frontiers in Neurology, 2022
BackgroundsStudies on risk factors influencing the prognosis of patients with sudden onset deafness are lacking.MethodsFrom March 2018 to March 2021, 500 patients, from the Tongde Hospital in Zhejiang Province, with sudden onset deafness were enrolled ...
Wei Lin, Gaoyun Xiong, Kailei Yan, Wumin Yu, Xiaoxing Xie, Ze Xiang, Jian Wu, Yanping Ge, Ying Wang   +8 more
doaj   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Conceptualizing, defining, and assessing pragmatic language impairment in clinical settings: A scoping review

Infant and Child Development, Volume 31, Issue 6, November/December 2022., 2022
Abstract There has been significant and extensive knowledge production in the last four decades regarding pragmatic language impairment (PLI) in children with neurodevelopmental disorders. The evidence contained in this literature, however, is contradictory. The present scoping review (ScR) seeks to disentangle competing explanations of conceptualizing,
Ahmed Alduais, Marinella Majorano, Clara Andrés‐Roqueta, Patricia Hamaguchi, Valentina Persici, Fawaz Qasem   +5 more
wiley   +1 more source

Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice

Molecular Therapy: Methods & Clinical Development, 2016
X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and is one of the most common causes of macular degeneration in young men.
Dario Marangoni, Ronald A Bush, Yong Zeng, Lisa L Wei, Lucia Ziccardi, Camasamudram Vijayasarathy, Joshua T Bartoe, Kiran Palyada, Maria Santos, Suja Hiriyanna, Zhijian Wu, Peter Colosi, Paul A Sieving   +12 more
doaj   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

A novel G21R mutation of the GJB2 gene causes autosomal dominant non-syndromic congenital deafness in a Cuban family

Genetics and Molecular Biology, 2006
Deafness is a complex disorder affecting 1/1000 infants. In developed countries, more than 50% of deafness cases are thought to have a genetic cause. At least 40 loci for dominant non-syndromic deafness and another 30 for recessive non-syndromic deafness
Raquel Rabionet, Estela Morales-Peralta, Núria López-Bigas, Maria Lourdes Arbonés, Xavier Estivill   +4 more
doaj   +1 more source

Interactive Employment Model to Assimilate the Deaf persons in workplace by using ICT [PDF]

Sindh Univ. Res. Jour. (Sci. Ser.) Vol. 45 (2) 263-266 (2013), 2013
The rate of disability is increase day by day all over the world .There are various type of Disabilities but the deaf persons are on second number among all types of disabilities.. In most of the countries disabled persons are supposed to be social liability on their family and in the society as awhile.
arxiv  

Effects of Non-Cognitive Factors on Post-Secondary Persistence of Deaf Students: An Agent-Based Modeling Approach [PDF]

arXiv, 2020
Post-secondary education persistence is the likelihood of a student remaining in post-secondary education. Although statistics show that post-secondary persistence for deaf students has increased recently, there are still many obstacles obstructing students from completing their post-secondary degree goals. Therefore, increasing the persistence rate is
arxiv  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26‐Week Results From the Phase 3 PaTHway Trial

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 14-25, January 2023., 2023
TransCon PTH is an investigational once‐daily prodrug providing sustained release of active PTH designed to maintain stable PTH levels in the physiological range for 24 hours/day. The PaTHway trial met all primary and key secondary endpoints with statistically significant differences from placebo. Most adverse events (AEs) were mild/moderate. Injection‐
Aliya A Khan, Mishaela R Rubin, Peter Schwarz, Tamara Vokes, Dolores M Shoback, Claudia Gagnon, Andrea Palermo, Claudio Marcocci, Bart L Clarke, Lisa G Abbott, Lorenz C Hofbauer, Lynn Kohlmeier, Susanne Pihl, Xuebei An, Walter Frank Eng, Alden R Smith, Jenny Ukena, Christopher T Sibley, Aimee D Shu, Lars Rejnmark   +19 more
wiley   +1 more source