Results 61 to 70 of about 94,072 (265)

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Cell Reports, 2015
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET ...
Kiyoto Kurima, Seham Ebrahim, Bifeng Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshiyuki Kawashima, Byung Yoon Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar   +14 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

The acoustic change complex as a diagnostic tool for cochlear dead regions evaluated in normally hearing adults

Scientific Reports
The loss of inner hair cells and/or neurons in the cochlea leads to cochlear dead regions (DRs). One of the consequences of DRs is noisy transmission of information from the cochlea to the brain, which results in poorer than expected perception of speech
Anna Schelenz, Emanuele Perugia, Lin Wu, Ewa Skrodzka, Karolina Kluk   +4 more
doaj   +1 more source

Familial Risk and Resilience Moderate the Association Between Intolerance of Uncertainty and Youth Suicidal Ideation

Journal of Clinical Psychology, EarlyView.
ABSTRACT Background Intolerance of uncertainty (IU), defined as a trait‐like tendency to respond to uncertain situations with negative cognitive, behavioral, and/or physiological reactions, is associated with increased risk for suicidal ideation (SI). Theory and research suggest that family‐level risk and resilience factors may shape how vulnerability ...
Alexa House, Shiane Toleson, Kathryn C. Jenkins, Kayla Kreutzer, Nicholas Allan, K. Luan Phan, Stephanie Gorka   +6 more
wiley   +1 more source

Clinical efficacy of mepolizumab and dupilumab for eosinophilic otitis media: Analysis of patient clinical characteristic

Allergology International
Background: Eosinophilic otitis media (EOM) is characterized by eosinophilic infiltration of the middle ear; it is frequently associated with bronchial asthma and chronic rhinosinusitis with nasal polyposis. Although biologics have been used to treat EOM,
Saori Kikuchi, Tomonori Sugiyama, Saemi Suzuki, Yukiko Iino   +3 more
doaj   +1 more source

CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer

Neoplasia: An International Journal for Oncology Research, 2014
Cancer stem cells (CSC) and genes have been linked to cancer development and therapeutic resistance, but the signaling mechanisms regulating CSC genes and phenotype are incompletely understood. CK2 has emerged as a key signal serine/threonine kinase that
Hai Lu, Carol Yan, Xin Xin Quan, Xinping Yang, Jialing Zhang, Yansong Bian, Zhong Chen, Carter Van Waes   +7 more
doaj   +1 more source

Comparison of Cranial Ultrasound and Amplitude‐Integrated Electroencephalography in Predicting Neurodevelopmental Outcomes in Neonates With Hypoxic–Ischemic Encephalopathy: A Systematic Review and Meta‐Analysis

Journal of Clinical Ultrasound, EarlyView.
In neonates with hypoxic–ischemic encephalopathy (HIE), adverse neurodevelopmental outcomes (NDO) remain common. Amplitude‐integrated EEG demonstrates strong prognostic value for early prediction, while cranial ultrasound (cUS) provides complementary but less definitive information.
Meirong Shu, Shilue Zhong, Bo Bao, Dandan Xu, Yingfeng Jiang, Dongxue Lin, Jingzhi Su   +6 more
wiley   +1 more source

Heritability and complex segregation analysis of deafness in Jack Russell Terriers

BMC Veterinary Research, 2007
Background The association between patterns of pigmentation and deafness in the dog has a long-documented history, with reports dating back over one hundred years.
Strain George M, Cargill Edward J, Famula Thomas R   +2 more
doaj   +1 more source

Correlations between appraisals, management strategies, and psychological stress among schoolchildren with ADHD—A pilot study

JCPP Advances, EarlyView.
Abstract Background Children with Attention‐Deficit/Hyperactivity Disorder (ADHD) encounter a range of difficulties in daily life. Guided by previous studies and theories, this pilot study examined whether distinct subgroups of children with ADHD could be identified based on their appraisals of the causes of their symptoms and the strategies they use ...
Noam Ringer, Adva Eichengreen
wiley   +1 more source

The genetics of deafness in domestic animals

Frontiers in Veterinary Science, 2015
Although deafness can be acquired throughout an animal’s life from a variety of causes, hereditary deafness, especially congenital hereditary deafness, is a significant problem in several species.
George M Strain
doaj   +1 more source