Results 101 to 110 of about 10,817,722 (406)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

High Death Rates: More Deaths or Earlier Deaths?

Journal of the Royal College of Physicians of London, 1987
In the analysis of mortality statistics high age-specific death rates could be interpreted as meaning more deaths (more disease), but they could equally well be interpreted as meaning earlier deaths (death at younger age). The distinction markedly affects the choice of hypotheses that may be advanced to explain variations in person, time and place and ...
openaire   +2 more sources

Moehewa: Death, lifestyle and sexuality in the Maori world [PDF]

, 2013
Customary death ritual and traditional practice have continued for the Maori (indigenous) people of Aotearoa/New Zealand, despite intensive missionary incursion and the colonial process.
Nikora, Linda Waimarie, Te Awekotuku, Ngahuia   +1 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Downstream changes in spring-fed stream invertebrate communities: the effect of increased temperature range?

Journal of Limnology, 2011
Reduced thermal amplitude has been highlighted as a limiting factor for aquatic invertebrate diversity in springs. Moving downstream water temperature range increases and invertebrate richness is expected to change accordingly.
Russell G. DEATH, José BARQU��N
doaj   +1 more source

Providing a health‐promotion behaviors model in elderly: Psychological capital, perceived social support, and attitudes toward death with mediating role of cognitive emotion regulation strategies

, 2022
Soliman Ahmadboukani, Davod Fathi, Mina Karami, Sepideh Bashirgonbadi, Abdolbaset Mahmoudpour, Behnam Molaei   +5 more
openalex   +1 more source

Pet Loss and Representations of Death, Attachment, Depression, and Euthanasia [PDF]

, 2017
T Studies that have examined pet loss hypothesize that attachment, representations of death, and the belief in an afterlife for animals may influence owners\u2019 bereavement and depressive outcomes.
De Cataldo, Loriana, Ronconi, Lucia, Testoni, Ines, Zamperini, Adriano   +3 more
core   +1 more source

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Journal of Hematology & Oncology, 2019
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage
Yan-hua Mou, Jun Wang, Jinchun Wu, D. He, Chunfang Zhang, Chaojun Duan, Bin Li   +6 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Programmed death‐ligand 1 expression in Epstein‐Barr virus positive nasopharyngeal cancer

, 2022
Abdulhameed Alfagih, M A Rahman, Sadeq Al‐Dandan, Salem Alrehaili, Tariq Ahmad Wani, Abdulrahim Al Malki, Ali Al Zahrani, Hatoon Bakhribah   +7 more
openalex   +1 more source