Results 131 to 140 of about 5,618,585 (312)
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.
The Lancet, 2012 R. Lozano, M. Naghavi, Kyle Foreman, S. Lim, K. Shibuya, V. Aboyans, J. Abraham, Tim Adair, Rakesh Aggarwal, S. Y. Ahn, Mohammad A. Almazroa, Miriam R. Alvarado, H. Anderson, Laurie M. Anderson, Kathryn G Andrews, C. Atkinson, L. Baddour, S. Barker-Collo, D. Bartels, Michelle L. Bell, Emelia J. Benjamin, D. Bennett, K. Bhalla, B. Bikbov, Aref A. Bin Abdulhak, G. Birbeck, F. Blyth, I. Bolliger, S. Boufous, C. Bucello, M. Burch, P. Burney, J. Carapetis, Honglei Chen, David P Chou, S. Chugh, Luc E. Coffeng, S. Colan, Samantha M. Colquhoun, K. Colson, J. Condon, M. Connor, M. Connor, Leslie T. Cooper, M. Corriere, Monica Cortinovis, Karen Courville de Vaccaro, W. Couser, Benjamin C. Cowie, M. Criqui, M. Cross, Kaustubh C Dabhadkar, N. Dahodwala, Diego De Leo, L. Degenhardt, A. Delossantos, J. Denenberg, D. C. D. Jarlais, S. Dharmaratne, E. Dorsey, T. Driscoll, H. Duber, Beth H. Ebel, P. Erwin, Patricia Espindola, M. Ezzati, V. Feigin, A. Flaxman, M. Forouzanfar, F. G. R. Fowkes, R. Franklin, M. Fransen, Michael Freeman, S. Gabriel, E. Gakidou, F. Gaspari, R. F. Gillum, D. González-Medina, Y. Halasa, D. Haring, James E. Harrison, Rasmus J. Havmoeller, Rasmus J. Havmoeller, Roderick J Hay, B. Hoen, Peter J. Hotez, D. Hoy, K. Jacobsen, S. James, Rashmi Jasrasaria, S. Jayaraman, N. Johns, G. Karthikeyan, N. Kassebaum, A. Keren, J. Khoo, L. Knowlton, O. Kobusingye, A. Koranteng, R. Krishnamurthi, M. Lipnick, S. Lipshultz, S. L. Ohno, J. Mabweijano, J. Mabweijano, Michael F. MacIntyre, Leslie Mallinger, L. March, Guy B. Marks, Robin Marks, A. Matsumori, R. Matzopoulos, R. Matzopoulos, B. Mayosi, J. Mcanulty, M. McDermott, J. Mcgrath, Ziad A. Memish, G. Mensah, T. Merriman, C. Michaud, Matthew Miller, Ted R. Miller, C. Mock, A. Mocumbi, A. Mokdad, A. Moran, K. Mulholland, M. Nair, L. Naldi, K. V. Narayan, K. Nasseri, P. Norman, M. O'Donnell, Saad B. Omer, K. Ortblad, Richard Osborne, D. Ozgediz, B. Pahari, J. Pandian, A. Rivero, R. Padilla, F. Pérez-Ruiz, N. Perico, D. Phillips, Kelsey Pierce, C. Pope, E. Porrini, F. Pourmalek, M. Raju, D. Ranganathan, Jürgen Rehm, David B Rein, G. Remuzzi, F. P. Rivara, Thomas J Roberts, F. Leòn, Lisa C. Rosenfeld, L. Rushton, Ralph L. Sacco, Joshua A. Salomon, Uchechukwu Sampson, Ella Sanman, D. Schwebel, M. Segui-Gomez, Donald S. Shepard, David Singh, J. Singleton, K. Sliwa, Emma Smith, A. Steer, Jennifer A. Taylor, Bernadette A. Thomas, I. Tleyjeh, J. Towbin, T. Truelsen, E. Undurraga, N. Venketasubramanian, L. Vijayakumar, T. Vos, G. Wagner, Mengru Wang, Wenzhi Wang, K. Watt, Martin A. Weinstock, R. Weintraub, J. Wilkinson, A. Woolf, Sarah K Wulf, P. Yeh, Paul Yip, A. Zabetian, Zhi-Jie Zheng, A. Lopez, Christopher J L Murray +194 moresemanticscholar +1 more sourceIdentification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan +10 morewiley +1 more sourceSubtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan +6 morewiley +1 more sourceGenetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova +25 morewiley +1 more sourceTargeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa +6 morewiley +1 more sourceRIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz +9 morewiley +1 more sourceN501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding
Signal Transduction and Targeted Therapy, 2021 Zubiao Niu, Zhengrong Zhang, Xiaoyan Gao, Peng Du, Jingjing Lu, Bohua Yan, Chenxi Wang, You Zheng, Hongyan Huang, Qiang Sun +9 moredoaj +1 more sourceProapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Science, 2001 M. Wei, W. Zong, E. Cheng, T. Lindsten, V. Panoutsakopoulou, Andrea J. Ross, K. Roth, G. MacGregor, C. Thompson, S. Korsmeyer +9 moresemanticscholar +1 more source
