Results 171 to 180 of about 10,693,133 (406)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

TMBIM6 INHIBITS APOPTOSIS OF VULNERABLE NEURONS IN PARKINSON´S DISEASE

IBRO Neuroscience Reports, 2023
Pablo Ahumada Montalva, Carolina Jerez, Sara Borquez, Francisco Muñoz, Melissa Nassif, Mario Sanhueza, Rene Vidal, Diego Rojas Rivera   +7 more
doaj   +1 more source

Age at onset and clinical course of RBM20-mediated cardiomyopathy

Scientific Reports
Disease-causative variants in RBM20-encoded RNA-binding motif protein 20 cause a severe arrhythmogenic dilated cardiomyopathy (DCM). We aimed to characterize the clinical course of RBM20-mediated DCM in comparison to other familial and non-familial forms
Ramin Garmany, Matteo Castrichini, Raquel Neves, Naveen L. Pereira, Ciorsti MacIntyre, Jay W. Schneider, Michael J. Ackerman, John R. Giudicessi   +7 more
doaj   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Resveratrol-loaded PLGA nanoparticles mediated programmed cell death in prostate cancer cells

, 2018
Anmar Nassir, Naiyer Shahzad, Ibrahim Abdel Aziz Ibrahim, Iqbal Ahmad, Shadab Md, Mohammad Ruhal Ain   +5 more
openalex   +1 more source

Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.

New England Journal of Medicine, 2004
A. Go, G. Chertow, Dongjie Fan, C. McCulloch, Chi-yuan Hsu   +4 more
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Experiencing patient death in clinical practice: Nurses’ recollections of their earliest memorable patient death

, 2014
Natalie Anderson, Bridie Kent, R. Glynn Owens   +2 more
openalex   +2 more sources

Immunogenic cell stress and death

Nature Immunology, 2022
G. Kroemer, C. Galassi, L. Zitvogel, L. Galluzzi   +3 more
semanticscholar   +1 more source