Results 201 to 210 of about 10,817,722 (406)

Screening for cardiac conditions associated with sudden cardiac death in the young : external review against programme appraisal criteria for the UK National Screening Committee [PDF]

, 2019
Bradlow, William, Clarke, Aileen, Couper, Keith, Field, Richard A., Perkins, Gavin D., Poole, Kurtis, Royle, Pamela, Taylor-Phillips, Sian, Yeung, Joyce   +8 more
core  

Immunogenic cell stress and death

Nature Immunology, 2022
G. Kroemer, C. Galassi, L. Zitvogel, L. Galluzzi   +3 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Studying asphyxiation in the lab: the role of experimental evidence in cause-of-death inquiry. [PDF]

Hist Philos Life Sci
Fischer E, Jukola S.
europepmc   +1 more source

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Cell, 1997
S. R. Datta, H. Dudek, Xu Tao, S. Masters, H. Fu, Y. Gotoh, M. Greenberg   +6 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

No pets allowed: Evidence that prolonged grief disorder can occur following the death of a pet. [PDF]

PLoS One
Hyland P.
europepmc   +1 more source

Antibiotic treatment adequacy and death among patients with Pseudomonas aeruginosa airway infection

, 2019
Josefin Eklöf, Kirstine Møller Gliese, Truls Sylvan Ingebrigtsen, Uffe Bødtger, Jens‐Ulrik Stæhr Jensen   +4 more
openalex   +2 more sources

Surgical Death [PDF]

, 1982
Schall, James V.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source