Results 31 to 40 of about 3,226,550 (274)
BMC Family Practice, 2020 Background General practitioners (GPs) increasingly manage patients with multimorbidity but report challenges in doing so. Patients describe poor experiences with health care systems that treat each of their health conditions separately, resulting in ...
Raechel A. Damarell +2 more
doaj +1 more source
Cell Death and Disease, 2023 SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells.
Srimanta Patra +8 more
doaj +1 more source
Blessing or Curse of Democracy?: Current Evidence from the Covid-19 Pandemic [PDF]
arXiv, 2021 Background: A major question in Covid-19 research is whether democracies handled the Covid-19 pandemic crisis better or worse than authoritarian countries. However, it is important to consider the issues of democracy versus authoritarianism, and state fragility, when examining official Covid-19 death counts in research, because these factors can ...
arxiv
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
, 2016 In nematodes, environmental or physiological perturbations alter death's scaling of time. In human cancer, genetic perturbations alter death's curvature of time. Those changes in scale and curvature follow the constraining contours of death's invariant geometry.
arxiv +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Different kinds of chimera death states in nonlocally coupled oscillators [PDF]
Phys. Rev. E 93, 052213 (2016), 2015 We investigate the significance of nonisochronicity parameter in a network of nonlocally coupled Stuart-Landau oscillators with symmetry breaking form. We observe that the presence of nonisochronicity parameter leads to structural changes in the chimera death region while varying the strength of the interaction.
arxiv +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Cells, 2022 Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with a wide range of pharmacological activities including anti ...
Ditte L. Fogde +9 more
doaj +1 more source
Deep neural networks for fine-grained surveillance of overdose mortality [PDF]
arXiv, 2022 Surveillance of drug overdose deaths relies on death certificates for identification of the substances that caused death. Drugs and drug classes can be identified through the International Classification of Diseases, 10th Revision (ICD-10) codes present on death certificates.
arxiv