Results 71 to 80 of about 2,688,047 (379)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Identification of pneumonia and influenza deaths using the death certificate pipeline

open access: yesBMC Medical Informatics and Decision Making, 2012
Background Death records are a rich source of data, which can be used to assist with public surveillance and/or decision support. However, to use this type of data for such purposes it has to be transformed into a coded format to make it computable ...
Davis Kailah   +4 more
doaj   +1 more source

Under Reporting of Dementia Deaths on Death Certificates: A Systematic Review of Population-based Cohort Studies

open access: yesJournal of Alzheimer's Disease, 2014
The purpose of this review is to assess the extent to which dementia is omitted as a cause of death from the death certificates of patients with dementia.
J. P. Romero   +3 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Maternal deaths databases analysis: Ecuador 2003-2013

open access: yesJournal of Public Health Research, 2016
Background: Maternal mortality ratio in Ecuador is the only millennium goal on which national agencies are still making strong efforts to reach 2015 target.
Antonio Pino   +3 more
doaj   +1 more source

Quality comparison of electronic versus paper death certificates in France, 2010

open access: yesPopulation Health Metrics, 2014
BackgroundElectronic death certification was established in France in 2007. A methodology based on intrinsic characteristics of death certificates was designed to compare the quality of electronic versus paper death certificates.MethodsAll death ...
D. Lefeuvre   +6 more
semanticscholar   +1 more source

Declining mortality from congenital heart disease in Malta [PDF]

open access: yes, 1997
Congenital heart disease (CHD) is the most common congenital anomaly occurring in approximately 10/1000 live births. Analysis of official Maltese Health Division statistics listing CHD as the primary cause of death on death•certificates has shown a ...
Attard Montalto, Simon   +2 more
core  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Group Life Insurance: Its Legal Aspects [PDF]

open access: yes, 1935
Background: Female representation on boards is an ongoing debate. The European Parliament voted in November 2013 in favour of a proposal that it should be at least 40 percent women on company boards by 2020.
Gustavsson, Jenny, Skeppstedt, Maria
core   +3 more sources

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