Results 61 to 70 of about 237,373 (344)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Assessment of the accuracy of death certification at two referral hospitals

Journal of Family and Community Medicine, 2008
Background : Death certification is a vital source of information used in mortality statistics worldwide to assess the health of the general population.This study focuses on the consistency of information between the death reports and the clinical ...
Abdulaziz A BinSaeed, Muslim M Al-Saadi, Khaldoon A AlJerian, Saad A Al-Saleh, Mosaad A Al-Hussein, Khalid S Al-Majid, Ziyad S Al-Sani, Khalid A Al-Rabeeah, Khalid A Arab, Khalid A Al-Sheikh, Sheik S Ahamed   +10 more
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Inadequacies of death certification in Beirut: who is responsible?

Bulletin of the World Health Organization
OBJECTIVE: To assess the completeness of data on death certificates over the past 25 years in Beirut, Lebanon, and to examine factors associated with the absence of certifiers' signatures and the non-reporting of the underlying cause of death. METHODS: A
Abla M. Sibai, Iman Nuwayhid, May Beydoun, Monique Chaaya   +3 more
doaj   +1 more source

What do people die from? The challenges of measuring disease burden posed by multi-morbidity. [PDF]

, 2015
Determining the precise cause of death of an individual has become increasingly difficult as life prolonging treatments mean that many people may die with multiple disorders, any of which, individually or in concert, might have killed them.
McKee, Martin
core   +1 more source

STRUCTURE AND FREQUENCY OF FATAL COMPLICATIONS OF DIABETES MELLITUS ACCORDING TO MEDICAL DEATH CERTIFICATES [PDF]

, 2021
Sh. Vaisman
openalex   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

An audit of the death certification process in Wales

Future Healthcare Journal
Introduction: Independent medical scrutiny and reforms to death certification became statutory in England and Wales in September 2024. Now all deaths are reported to the Medical Examiner Services (MES) for them to be scrutinised by an independent medical
Indrajit Nair, V Adhiyaman
doaj   +1 more source

Improving medical certification of cause of death: effective strategies and approaches based on experiences from the Data for Health Initiative

BMC Medicine, 2020
Background Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration ...
John D. Hart, Renee Sorchik, Khin Sandar Bo, Hafizur R. Chowdhury, Saman Gamage, Rohina Joshi, Viola Kwa, Hang Li, Buddhika P. K. Mahesh, Deirdre Mclaughlin, Lene Mikkelsen, Janet Miki, Roderick Napulan, Rasika Rampatige, Matthew Reeve, Carmina Sarmiento, Nang Su War, Nicola Richards, Ian D. Riley, Alan D. Lopez   +19 more
doaj   +1 more source