Results 211 to 220 of about 49,393,497 (356)

Psychological and behavioural responses to death anxiety in older adults with chronic illnesses: a systematic integrative review. [PDF]

Front Psychol
Alcântara L, Figueiredo T, Midão L, Costa E, Paúl C.   +4 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Postmortem Microbiology in Forensic Diagnostics: Interpretation of Infectious Causes of Death and Emerging Applications. [PDF]

Diagnostics (Basel)
Camatti J, Bonasoni MP, Santunione AL, Cecchi R, Radheshi E, Carretto E.   +5 more
europepmc   +1 more source

Acute intestinal radiation death. Studies on roentgen death in mice, III.

American Journal of Physiology, 1951
H. Quastler, E. F. Lanzl, Mildred E. Keller, J. W. Osborne   +3 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

General and abdominal adiposity and risk of death in Europe.

New England Journal of Medicine, 2008
T. Pischon, H. Boeing, K. Hoffmann, M. Bergmann, M. Schulze, K. Overvad, Y. T. V. D. Schouw, E. Spencer, K. Moons, A. Tjønneland, J. Halkjær, M. Jensen, J. Stegger, F. Clavel-Chapelon, M. Boutron‐Ruault, V. Chajès, J. Linseisen, R. Kaaks, A. Trichopoulou, D. Trichopoulos, C. Bamia, S. Sieri, D. Palli, R. Tumino, P. Vineis, S. Panico, P. Peeters, A. May, H. Bueno-de-Mesquita, F. V. Duijnhoven, G. Hallmans, L. Weinehall, J. Manjer, B. Hedblad, E. Lund, A. Agudo, L. Arrióla, A. Barricarte, C. Navarro, Carlos Martinez, J. Quirós, T. Key, S. Bingham, K. Khaw, P. Boffetta, M. Jenab, P. Ferrari, E. Riboli   +47 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bridging the Gaps: Complexities and Challenges in Studying SUDEP Using Animal Models. [PDF]

Epilepsy Curr
Najeeb M, Shen Y, Gu B.
europepmc   +1 more source