Results 1 to 10 of about 499,982 (305)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Rise velocity of small polyolefin plastics in a seawater tank exposed to natural conditions in Hawai’i

Environmental Research Communications
Floating plastic is ubiquitous at the ocean surface, but the transport mechanisms associated with the type of particle and the effect of environmental parameters, including the presence of a biofilm on the polymers, are very limited.
Sarah-Jeanne Royer, Kayla C Brignac, Ferenc Ronkay, Kellie Teague, Granya Morris, Jennifer Lynch, Laurent Lebreton   +6 more
doaj   +1 more source

Comparative analysis of cleaning ability of three nickel-titanium rotary systems: ProTaper universal, K3 and Mtwo: An in vitro scanning electron microscopic study

Nigerian Postgraduate Medical Journal, 2016
Background: Endodontic instruments including the nickel-titanium (NiTi) instruments produce debris and smear layer during instrumentation. The study was carried out to evaluate and compare the cleaning effectiveness of root canal preparation using three ...
Ambar W Raut, Vijay Mantri, Aparna Palekar, Rupal Gadodia, Shubham Kala, Radha A Raut   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Plastic ingestion by North Pacific garbage patch fishes: highest occurrences and quantities in upper trophic pelagics

Environmental Research Communications
Plastic marine debris (PMD) is rapidly accumulating in the North Pacific Subtropical Gyre, exposing fishes living in the North Pacific garbage patch (NPGP) to extremely high PMD concentrations.
Katherine R Shaw, Zachary D Bramble, Sarah-Jeanne Royer, Matthias Egger, Matthew Iacchei, Jennifer M Lynch, K David Hyrenbach   +6 more
doaj   +1 more source

STar-DETR: A Lightweight Real-Time Detection Transformer for Space Targets in Optical Sensor Systems

Sensors
Optical sensor systems are essential for space target detection. However, previous studies have prioritized detection accuracy over model efficiency, limiting their deployment on resource-constrained sensors.
Yao Xiao, Yang Guo, Qinghao Pang, Xu Yang, Zhengxu Zhao, Xianlong Yin   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Multi-Faceted Debris-Flood Hazard Assessment for Cougar Creek, Alberta, Canada

Hydrology, 2017
A destructive debris flood occurred between 19 and 21 June 2013 on Cougar Creek, located in Canmore, Alberta. Cougar Creek fan is likely the most densely developed alluvial fan in Canada.
Matthias Jakob, Hamish Weatherly, Stephanie Bale, Ashley Perkins, Brent MacDonald   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source