Results 101 to 110 of about 1,117,135 (403)

A Survey for Massive Giant Planets in Debris Disks with Evacuated Inner Cavities [PDF]

, 2007
The commonality of collisionally replenished debris around main sequence stars suggests that minor bodies are frequent around Sun-like stars. Whether or not debris disks in general are accompanied by planets is yet unknown, but debris disks with large ...
A. Moro‐Martin, B. Biller, D. Apai, E. E. Mamajek, E. Masciadri, I. Pascucci, J. S. Kim, L. A. Hillenbrand, M. Janson, M. Kasper, M. R. Meyer, Mueller M., Quillen A. C., Th. Henning   +13 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Numerical simulation of debris flows triggered from the Strug rock fall source area, W Slovenia [PDF]

, 2006
The Strug landslide was triggered in December 2001 as a rockslide, followed by a rock fall. In 2002, about 20 debris flows were registered in the Kosec village; they were initiated in the Strug rock fall source area.
Fazarinc, Rok, Hojnik, Tomaž, Krzyk, Mario, Majes, Bojan, Mikoš, Matjaž, Rajar, Rudolf, Četina, Matjaž, Žagar, Dušan   +7 more
core   +1 more source

Ablation debris control by means of closed thick film filtered water immersion [PDF]

, 2010
The performance of laser ablation generated debris control by means of open immersion techniques have been shown to be limited by flow surface ripple effects on the beam and the action of ablation plume pressure loss by splashing of the immersion fluid ...
Bickel W. S., Bowling R. A., C F Dowding, Dyer P. E., Dyer P. E., Hutcheson G. D., J Lawrence, Lifshitz E. M., Munson B. R.   +8 more
core   +1 more source

Planetesimal/Debris Disks

, 2023
Review chapter of the book "Planetary Systems Now", to be published by World ...
openaire   +2 more sources

Modeling debris-covered glaciers: response to steady debris deposition [PDF]

The Cryosphere, 2016
Abstract. Debris-covered glaciers are common in rapidly eroding alpine landscapes. When thicker than a few centimeters, surface debris suppresses melt rates. If continuous debris cover is present, ablation rates can be significantly reduced leading to increases in glacier length.
Leif S. Anderson, Robert S. Anderson
openaire   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Hydrodynamic Ram Effect Caused by Debris Hypervelocity Impact on Satellite Tank

Applied Sciences, 2019
To study the hydrodynamic ram effect caused by the debris hypervelocity impact on the satellite tank, a numerical simulation of the spherical debris impacting the satellite tank at the velocity of 7000 m/s was carried out based on ANSYS/LS-DYNA software.
Beilei Zhao, Jiguang Zhao, Cunyan Cui, Yongsheng Duan   +3 more
doaj   +1 more source

Quantitative evaluation of apically extruded debris in root canals prepared by single-file reciprocating and single file rotary instrumentation systems: A comparative In vitro study

Journal of Pharmacy and Bioallied Sciences, 2021
Background: Prevention of the debris from extruding to the periapical region is an important aspect to be taken care of as its extrusion can result in pain, periapical inflammation, and delayed healing owing to the presence of highly infective components
Sonal Sinha, Konark Singh, Anju Singh, Swati Priya, Avanindra Kumar, Sahil Kawle   +5 more
doaj   +1 more source