Results 231 to 240 of about 14,509 (263)

Lovastatin‐Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle‐Puncture Induced Degeneration Model in Rat Caudal Discs

open access: yesJOR SPINE, Volume 8, Issue 4, December 2025.
Lovastatin‐loaded nanoparticles were developed and incorporated into a thermosensitive chitosan hydrogel for treating intervertebral disc degeneration, showing sustained lovastatin release and enhanced production of aggrecan and Type II collagen in human nucleus pulposus cells in vitro. Animal studies using a rat caudal disc model mimicking early stage
Chih‐Wei Chen   +7 more
wiley   +1 more source

An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell‐Based Grafts

open access: yesJOR SPINE, Volume 8, Issue 4, December 2025.
An ex vivo model of intervertebral disc (IVD) degeneration was generated using chondroitinase ABC (ChABC) and pro‐inflammatory cytokines (Infl) and used for assessing retention of injectable cell‐based grafts, namely nasal chondrocyte spheroids (NCS). ABSTRACT Introduction Cell therapies for painful intervertebral disc (IVD) degeneration (IDD) have not
Raphael Schmid   +13 more
wiley   +1 more source

Whole‐genome sequencing bulked segregant analysis uncovered FW7, a Fusarium wilt resistance gene masked by epistasis in octoploid strawberry

open access: yesThe Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Fusarium wilt, a vascular disease of strawberry (Fragaria ×$\times$ ananassa) caused by the soilborne fungal pathogen Fusarium oxysporum f. sp. fragariae, has emerged over the past 20 years as a leading cause of severe plant wilt and death in California and many other parts of the world. We previously described several sources of resistance to
Mishi V. Vachev   +12 more
wiley   +1 more source

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