Results 71 to 80 of about 14,509 (263)

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Tidal Disruption of Planetesimals from an Eccentric Debris Disk Following a White Dwarf Natal Kick

The Astrophysical Journal Letters
The surfaces of many white dwarfs are polluted by metals, implying a recent accretion event. The tidal disruption of planetesimals is a viable source of white dwarf pollution and offers a unique window into the composition of exoplanet systems.
Tatsuya Akiba, Selah McIntyre, Ann-Marie Madigan   +2 more
doaj   +1 more source

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

Advanced Science, EarlyView.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou, Yukiko Iwasaki, Willy Lutz, Glaucia Almeida, Emilie Béchard, François Delalande, Magali Rompais, Jules Bouget, Barbara Gorda, Chantal Cazevieille, Yonis Bare, Christine Carapito, Sophie Colomb, Gowrishankar Ganesh, Raphael Gaudin   +14 more
wiley   +1 more source

Polarization of Circumstellar Debris Disk Light Echoes

The Astronomical Journal
Light echoes of debris disks around active stars can reveal disk structure and composition even when disks are not spatially resolved. Unfortunately, distinguishing reflected light from quiescent starlight and unexpected post-peak flare structure is ...
Austin J. King, Benjamin C. Bromley, Preston W. Harris, Scott J. Kenyon   +3 more
doaj   +1 more source

Insights into Planet Formation from Debris Disks: I. The Solar System as an Archetype for Planetesimal Evolution [PDF]

, 2016
Brenda C. Matthews, J. J. Kavelaars
openalex   +1 more source

Mechanical Force Storage and Reprogramming Hydrogel for Scarless Repair of Sports Joint Wounds

Advanced Science, EarlyView.
Inspired by the energy conversion of tendons, the “energy transit station” hydrogel is designed. The hydrogel not only shields stress concentration in sports injuries, but also reprograms energy forms to provide reasonable biomimetic contraction for wounds.
Jiakang Zhang, Yuhui Zhang, Yuanru Lang, Tao Fu, Qian Liu, Long Chen, Peng Zhang, Yan Xiao, Yuntong Zhang, Shuo Fang, Meidong Lang   +10 more
wiley   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Follow-up Exploration of the TWA 7 Planet–Disk System with JWST NIRCam

The Astrophysical Journal Letters
The young M star TWA 7 hosts a bright and near face-on debris disk, which has been imaged from the optical to the submillimeter. The disk displays multiple complex substructures such as three disk components, a large dust clump, and spiral arms ...
Katie A. Crotts, Aarynn L. Carter, Kellen Lawson, James Mang, Beth Biller, Mark Booth, Rodrigo Ferrer-Chavez, Julien H. Girard, Anne-Marie Lagrange, Michael C. Liu, Sebastian Marino, Maxwell A. Millar-Blanchaer, Andy Skemer, Giovanni M. Strampelli, Jason Wang, Olivier Absil, William O. Balmer, Raphaël Bendahan-West, Ellis Bogat, Rachel Bowens-Rubin, Gaël Chauvin, Clémence Fontanive, Kyle Franson, Jens Kammerer, Jarron Leisenring, Caroline V. Morley, Isabel Rebollido, Nour Skaf, Ben J. Sutlieff, Evelyn L. Bruinsma, Sasha Hinkley, Kielan Hoch, Andrew D. James, Rohan Kane, Dimitri Mawet, Michael R. Meyer, Skyler Palatnick, Marshall D. Perrin, Shrishmoy Ray, Emily Rickman, Aniket Sanghi, Klaus Subbotina Stephenson   +41 more
doaj   +1 more source

Impact of planetesimal eccentricities and material strength on the appearance of eccentric debris disks [PDF]

, 2018
M. Kim, S. Wolf, T. Löhne, Florian Kirchschlager, A. V. Krivov   +4 more
openalex   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source