Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration
JOR SPINE, Volume 9, Issue 1, March 2026.This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump +8 more
wiley +1 more source
Correction to: Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors. [PDF]
Hum Mol Geneteuropepmc +1 more source
Polydopamine-Coated Magnetic Nanoplatform for Magnetically Guided Penetration and Enhanced Antibacterial Efficacy in Root Canal Biofilm Elimination. [PDF]
Polymers (Basel)Xu X +6 more
europepmc +1 more source
JOR SPINE, Volume 9, Issue 1, March 2026.Goat nucleus pulposus cells cultured under clinically relevant oxygen, glucose, pH, and osmolarity revealed pH to have the most influential impact on viability and glycosaminoglycan synthesis. Interactions between factors showed that disc cell behavior is shaped by the microenvironment, highlighting its importance in regenerative therapy design for the
Niamh Wilson +5 more
wiley +1 more source
Impact of exercise on immune cell infiltration in muscle tissue: implications for muscle repair and chronic disease. [PDF]
Clin Exp MedSu Y, Su Z.
europepmc +1 more source
Responses of Root Microbiome and Metabolome Are Linked to Crop Disease Severity
Journal of Sustainable Agriculture and Environment, Volume 5, Issue 1, March 2026.ABSTRACT Plant microorganisms are an essential component of the host and perform critical functions in plant development and health. Emerging evidence shows that plants use their root exudates to recruit beneficial microbes that protect them against abiotic and biotic stresses, including diseases.
Ayomide Emmanuel Fadiji +1 more
wiley +1 more source
Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.Human mesenchymal stem cells conditionally secrete sonic hedgehog (SHH)‐containing extra‐large extracellular vesicles (XLEVs) upon PI3K activation, which enriches the GDP‐bound form of Rab18. Rab18‐GDP drives perinuclear maturation and polarized vertical release of SHH‐XLEVs via Hsp90α‐ and nSMase2‐dependent mechanisms.
Shuo Wang +3 more
wiley +1 more source
Stable, bioactive hydrogel coating on silicone surfaces for non-invasive decontamination via photochemical treatment. [PDF]
Bioact MaterBerger R +8 more
europepmc +1 more source
Efficient and rapid isolation of native AMPA receptor complexes for cryo‐EM
Protein Science, Volume 35, Issue 2, February 2026.Abstract Isolating native ion channels for structural characterization is routinely achieved by extraction from membrane fractions of tissue with prolonged mild detergent treatment. AMPA receptors (AMPARs), glutamatergic receptors that mediate fast excitatory transmission and synaptic plasticity, are coassembled with diverse auxiliary subunits and ...
Jumi Park, Eric Gouaux
wiley +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong +9 more
wiley +1 more source