Results 221 to 230 of about 5,550,692 (265)

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

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Observations and Analyses of the 9 January 2018 Debris-Flow Disaster, Santa Barbara County, California

, 2021
The post–Thomas Fire debris flows of 9 January 2018 killed 23 people, damaged 558 structures, and caused severe damage to infrastructure in Montecito and Carpinteria, CA. U.S.
J. Lancaster, B. Swanson, S. Lukashov, N. Oakley, Jacob B. Lee, E. Spangler, Janis L. Hernandez, B. Olson, M. DeFrisco, D. Lindsay, Y. Schwartz, S. McCrea, P. Roffers, Christopher M. Tran   +13 more
semanticscholar   +1 more source

Two-phase SPH numerical study of pore-water pressure effect on debris flows mobility: Yu Tung debris flow

, 2021
A debris flow is one of the most dangerous types of geophysical mass flows moving downward mountain slopes and consist of a mixture of soil and rocks with a significant quantity of interstitial fluid.
S. M. Tayyebi, M. Pastor, M. Stickle
semanticscholar   +1 more source

An augmented representation method of debris flow scenes to improve public perception

International Journal of Geographical Information Science, 2020
Virtual scenes can present rich and clear disaster information, which can significantly improve the level of public disaster perception. However, existing methods for constructing scenes of debris flow disasters have some deficiencies.
Wei-Lian Li, Jun Zhu, Lin Fu, Qing Zhu, Ya-Kun Xie, Ya Hu   +5 more
semanticscholar   +1 more source

Effect of slit size on the impact load against debris-flow mitigation dams

, 2020
Structural countermeasures such as slit dams and check dams are widely installed in mountainous regions to mitigate debris-flow hazards. However, current approaches adopted to estimate debris-flow impact load only depend on the flow properties without ...
Hongsen Hu, Gordon G. D. Zhou, D. Song, K. Cui, Yu Huang, C. Choi, Hua-Yong Chen   +6 more
semanticscholar   +1 more source

AI-based identification of low-frequency debris flow catchments in the Bailong River basin, China

, 2020
Debris flow is a major geohazard in mountainous regions and poses a significant threat to life and property. The damage caused by debris flows have increased with the expansion of human settlements and activity into the mountainous regions of China.
Yan Zhao, Xingmin Meng, Tian-jun Qi, Feng Qing, Mu-Qi Xiong, Ya-Jun Li, P. Guo, Guan Chen   +7 more
semanticscholar   +1 more source

Intermittent viscous debris flow formation in Jiangjia Gully from the perspectives of hydrological processes and material supply

, 2020
Debris flows are among the most destructive natural processes to affect areas of mountainous terrain. Debris flow formation involves watershed-scale processes of hydrology and material supply.
Xiao-Jun Guo, Yong Li, P. Cui, Huai-De Yan, Jian-Qi Zhuang   +4 more
semanticscholar   +1 more source

A physics-based model to derive rainfall intensity-duration threshold for debris flow

, 2020
A statistical method to establish an intensity-duration curve (I-D curve) for debris flows is highly dependent on a large amount of debris flows and rainfall events and is impossible for a gully lacking observation data.
Suo-Jiang Zhang, Chang-Xue Xu, F. Wei, Kai-Heng Hu, H. Xu, L.-Q. Zhao, Guoping Zhang   +6 more
semanticscholar   +1 more source

Numerical investigation of the landslide-debris flow transformation process considering topographic and entrainment effects: a case study

Landslides, 2022
Jian Guo, Yi-fei Cui, Wen-Jie Xu, Yanzhou Yin, Yao Li, W. Jin   +5 more
semanticscholar   +1 more source