Results 251 to 260 of about 150,634 (313)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Macroplastic accumulation across different surface covers, a case study of two South African rivers. [PDF]

Sci Rep
Mutshekwa T, Mlambo MC, Mbadla L, Mkhencele S, Mofu L, Osoh MO, Motitsoe SN.   +6 more
europepmc   +1 more source

One-dimensional Mathematical Modelling of Debris Flow Impact on Open-check Dams

, 2016
Luca Cozzolino, Veronica Pepe, Renata Della Morte, Vincenzo Cirillo, Andrea D’Aniello, Luigi Cimorelli, Carmine Covelli, Francesco Morlando, Domenico Pianese   +8 more
openalex   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Study on debris flow vulnerability of ensemble learning model based on spy technology A case study of upper Minjiang river basin. [PDF]

Sci Rep
Chen Y, Li N, Xing F, Xiang H, Chen Z.
europepmc   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Modeling Debris Flow Events in the Rio Inferno Watershed (Italy) Through UAV-Based Geomorphological Survey and Rainfall Data Analysis. [PDF]

Sensors (Basel)
Turbessi L, Taboni B, Umili G, Fubelli G, Ferrero AM.   +4 more
europepmc   +1 more source

Mechanism of enhanced mobility of glacial debris flows induced by ice and rock avalanches in southeast Tibet, China: Insights from impact loading tests [PDF]

Yao Jiang, Xingsheng Lu, Jiao Wang, Guotao Zhang, Gonghui Wang, Tao Wang, Zhi Zhang, Tianyi Ren, Haotian Lu   +8 more
openalex   +1 more source

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

Advanced Science, EarlyView.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yan   +7 more
wiley   +1 more source

Supplementary material to "Erosion after an extreme storm event in an arid fluvial system of the southern Atacama Desert: an assessment of magnitude, return time, and conditioning factors of erosion caused by debris flows"

, 2019
Germán Aguilar, Albert Cabré, Víctor Fredes, Bruno Villela   +3 more
openalex   +1 more source