Results 41 to 50 of about 150,634 (313)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Influence of fine sediment on the fluidity of debris flows [PDF]

, 2013
Debris flows include a great diversity of grain sizes with inherent features such as inverse grading, particle size segregation, and liquefaction of fine sediment.
Hotta Norifumi, Iwata Tomoyuki, Kaneko Takahiro, Nishimoto Haruo, 堀田 紀文, 西本 晴男   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A Review of Research on the Stability of Fine-Grained Sediments in Debris Flows

Geosciences
Fine-grained sediments in debris flows refer to Quaternary sediments with grain sizes smaller than 2 mm. Their stability is closely related to the initial water threshold that triggers the debris flows and thus controls the density, scale, and damage of ...
Qinjun Wang, Jingyi Yang, Wentao Xu, Boqi Yuan, Chaokang He   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Study of pore fluid effect on the mobility of granular debris flows

EPJ Web of Conferences, 2017
Granular debris flows in nature are composed of a wide range of solids and viscous pore fluids, moving at high velocities down sloping channels. The pore fluids in a granular debris flow affect the interactions between the solid and fluid phases and thus
Zhou Gordon G. D., Sun Q. C.
doaj   +1 more source

Processes in model slopes made of mixtures of wettable and water repellent sand: Implications for the initiation of debris flows in dry slopes [PDF]

, 2015
Debris flows in slopes initially dry, such as post-wildfire debris flows, are initiated by surface runoff and sediment bulking due to reduced infiltration.
Arye, Atanassova, Bachmann, Bachmann, Bachmann, Beatty, Busscher, Byun, Cannon, Capra, Chenu, Coe, De Gennes, Dekker, Doerr, Doerr, Doerr, Ellen, Escario, Fisher, Fisher, Fisher, Fredlund, Gabet, Gong-Hui Wang, Granged, Hoffman, Houston, Hubbert, Iverson, Jackson, Karagunduz, Kean, Li, Liu, Lourenço, Mallik, McDonnell, Moody, Moody, Morley, Ritsema, Siemens, Sérgio D.N. Lourenço, Taniguchi, Toshitaka Kamai, Wang, Wang, Wondzell, Woods   +49 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Direct Detection of Dark Matter Debris Flows

, 2012
Tidal stripping of dark matter from subhalos falling into the Milky Way produces narrow, cold tidal streams as well as more spatially extended "debris flows" in the form of shells, sheets, and plumes. Here we focus on the debris flow in the Via Lactea II
David N. Spergel, M. Boylan-Kolchin, Mariangela Lisanti, Michael Kuhlen, S. R. Majewski   +4 more
core   +1 more source