Results 51 to 60 of about 150,634 (313)

DEBRIS FLOWS IN VAL PARMA AND VAL BAGANZA (NORTHERN APENNINES) DURING THE 12-13TH OCTOBER 2014 ALLUVIAL EVENT IN PARMA PROVINCE (ITALY) [PDF]

open access: yes, 2017
During the 13 October 2014 rainstorm event that affected the Val Parma and Val Baganza area, several debris flows affected the Mt. Cervellino relief (northern Apennines, Italy), causing severe and widespread damages to check-dams, roads and other ...
Alberoni, P. P.   +5 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Numerical model derived intensity-duration thresholds for early warning of rainfall-induced debris flows in the Himalayas [PDF]

open access: gold, 2023
Srikrishnan Siva Subramanian   +4 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Experimental Investigation into the Number of Phases in Debris Flows

open access: yesApplied Sciences
Controversial number of phases in debris-flow masses involves almost all areas of debris-flow research. In this study, we experimentally investigated the number of phases in fully developed debris flows using six sediments with three maximum diameters of
Bin Li, Ze-Min Xu
doaj   +1 more source

Investigation of Post-Fire Debris Flows in Montecito

open access: yesISPRS International Journal of Geo-Information, 2018
Debris flows in a burned area, post-fire debris flows, are considered as one of the most dangerous geo-hazards due to their high velocity, long run-out distance, and huge destruction to infrastructures.
Yifei Cui, Deqiang Cheng, Dave Chan
doaj   +1 more source

RRS Charles Darwin Cruise 126, 11 Mar-20 Mar 2001. Piston coring of debris flows and turbidites west and south of the Canary Islands [PDF]

open access: yes, 2002
The major cruise objective was to obtain sediment cores at various locations to the west and southwest of the Canary Islands with the aims of :· Sampling debris flow sediments in the Canary and Saharan debris flows· Obtaining dateable sediments ...
Masson, D.G.
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Lattice-Boltzmann Method for Geophysical Plastic Flows

open access: yes, 2015
We explore possible applications of the Lattice-Boltzmann Method for the simulation of geophysical flows. This fluid solver, while successful in other fields, is still rarely used for geotechnical applications.
C. Ancey   +19 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Home - About - Disclaimer - Privacy