Results 61 to 70 of about 150,634 (313)

Research on the comprehensive control technology system of large-scale debris flows in the area affected by strong earthquake in Longmenshan, Sichuan Province

Zhongguo dizhi zaihai yu fangzhi xuebao
In response to the challenges posed by frequent, widespread, long-lasting, large-scale, severe, and difficult-to-control debris flows in strong earthquake areas, this study, based on the results of the National Key R&D Program, investigates dozens of ...
Lu GAO, Songjiang ZHAO, Tao YANG, Xiewen HU, Bin YU   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Effects of Glacier and Geomorphology on the Mechanism Difference of Glacier-Related Debris Flow on the South and North Banks of Parlung Zangbo River, Southeastern Tibetan Plateau

Advances in Civil Engineering, 2022
Alpine glaciers are vulnerable to climate changes, and their recession due to warming has already induced a large number of geohazards closely related to the glacial motion, such as debris flow. Strong coupling of the geology, geomorphology, climate, and
Jiajia Zhang, Jiankang Liu, Yuanling Li, Junchao Wang, Long Chen, Bo Gao   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Experimental investigations of granular matter flow regimes leading to insight into lahar flow dynamics : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Earth Science at Massey University, Manawatū, New Zealand [PDF]

, 2016
The flow of granular material governs numerous natural processes including the aeolian dynamics of sand dune formation, sub-aerial and submarine mass flows, the collective dynamics of ice blocks floating on the ocean, avalanches of debris and snow, as
Neather, Adam Charles
core  

Variable selection based on entropic criterion and its application to the debris-flow triggering [PDF]

, 2006
We propose a new data analyzing scheme, the method of minimum entropy analysis (MEA), in this paper. New MEA provides a quantitative criterion to select relevant variables for modeling the physical system interested. Such method can be easily extended to
Caticha, Chen, Chen, Chen, Chen, Chen, Chien-chih Chen, Chih-Yuan Tseng, Davis, Dupuis, Forbes, Jan, Jaynes, Jaynes, Jaynes, Jia-Jyun Dong, Johnson, Lin, Lin, Lin, Lin, Raftery, Rundle, Rupert, Skilling, Takahashi, Tseng, Weiss, Wieczorek   +28 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Mid- and Long-Term Effects of Wildfire and Debris Flows on Stream Ecosystem Metabolism [PDF]

, 2016
Wildfire is an important and prevalent agent of disturbance in vegetated landscapes across much of the Earth’s surface, including forested watersheds in the arid western USA.
Koetsier, Peter, Tuckett, Quenton M.
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source