Results 71 to 80 of about 150,634 (313)
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Rainfall characteristics for periglacial debris flows in the Swiss Alps: past incidences-potential future evolutions [PDF]
, 2018 Based on observational meteorological data since A.D. 1864 and tree-ring records of debris-flow activity, this paper assesses changes in rainfall characteristics and their impact on the triggering of geomorphic events in a high-elevation watershed of the
Beniston, Martin +2 more
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
npj Natural HazardsDebris flows, caused by Glacier Lake Outburst Floods (GLOF) or extreme weather, threaten lives and infrastructure in the northern Tien Shan. A geo-referenced database of 458 debris flow events of different geneses was compiled for the region.
Maria Shahgedanova +8 more
doaj +1 more source
Геодинамика и тектонофизика, 2016 On 28 June 2014, debris flows brought large volumes of loose material into the Kyngarga river valley. The material was sourced from rock collapse and rock sliding on the valley slopes and delivered mainly to the river by debris flows from the side ...
A. V. Kadetova +4 more
doaj +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Field monitoring of pore water pressure in fully and partly saturated debris flows at Ohya landslide scar, Japan [PDF]
Earth Surface DynamicsThe characteristics of debris flows (e.g., mobility, sediment concentration, erosion, and deposition of sediment) are dependent on the pore water pressure in the flows.
S. Oya, F. Imaizumi, S. Takayama
doaj +1 more source
Modelling debris flows down general channels [PDF]
, 2005 This paper is an extension of the single-phase cohesionless dry granular avalanche model over curved and twisted channels proposed by Pudasaini and Hutter (2003).
K. Hutter, S. P. Pudasaini, Y. Wang
core +2 more sources
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
The Seismic Signature of Debris Flows: Flow Mechanics and Early Warning at Montecito, California [PDF]
, 2018 Debris flows are concentrated slurries of water and sediment that shape the landscape and pose a major hazard to human life and infrastructure. Seismic ground motion‐based observations promise to provide new, remote constraints on debris flow physics ...
Beer, Alexander R. +4 more
core