Results 121 to 130 of about 1,196,152 (257)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Oceanic planetary waves in the coupled ocean-atmosphere system [PDF]

, 2005
The propagation of planetary, or Rossby, waves is studied under the effects of different atmospheric couplings. First, analytical matchings are formulated in which a Rossby wave is coupled to different thermodynamical atmospheres, from a simple heat flux
Farneti, R.
core   +1 more source

Correction to 'Inter-decadal variability of phytoplankton biomass along the coastal West Antarctic Peninsula'. [PDF]

Philos Trans A Math Phys Eng Sci, 2020
Kim H, Ducklow HW, Abele D, Ruiz Barlett EM, Buma AGJ, Meredith MP, Rozema PD, Schofield OM, Venables HJ, Schloss IR.   +9 more
europepmc   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Sea-level change and storm surges in the context of climate change [PDF]

, 2000
This paper reviews the latest research in New Zealand surrounding the issues of sea-level rise and extreme sea levels in the context of global warming and variability in the Pacific-wide El Nino– Southern Oscillation (ENSO).
Bell, Robert G., de Lange, Willem P., Goring, D. G.   +2 more
core  

Decadal variability and recent summer warming amplification of the sea surface temperature in the Red Sea. [PDF]

PLoS One, 2020
Alawad KA, Al-Subhi AM, Alsaafani MA, Alraddadi TM.   +3 more
europepmc   +1 more source

Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Individuals with systemic lupus erythematosus (SLE) can accumulate functional status (FS) impairment. We evaluated the association between neighborhood socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), and FS in a national SLE sample.
Baljeet Rai, Jessica Fitzpatrick, Jing Li, Eric Roberts, Patricia Katz, Laura Plantinga, Gabriela Schmajuk, Jinoos Yazdany   +7 more
wiley   +1 more source

Decadal rainfall variability over Southern Africa [PDF]

, 2008
Southern Africa is a region of vulnerability, with high seasonal and interannual rainfall variability combined with rain-dependent agriculture. This variability is underpinned by influences from ENSO and other oceanic forcing, and known to exhibit quasi ...
Preece, David John
core  

A model study of decadal climate variability and predictability associated with the Atlantic meridional overturning circulation

, 2012
This study addresses the decadal variability and predictability of the Atlantic Meridional Overturning Circulation (AMOC), and associated key variables, in two IPCC-class climate models.
Persechino, Aurelie S.A.
core   +1 more source