Results 101 to 110 of about 12,835 (293)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Decadence and Fashion: Full Issue

open access: yes, 2023
Volupté 6.2 Decadence and Fashion: Full ...
Journal, Volupté
core   +1 more source

Die stille Sprache der Stadt: Prag in Paul Leppins Roman Severins Gang in die Finsternis // The Silent Language of the City: Prague in Paul Leppin’s Severin’s Journey into the Dark [PDF]

open access: yesSlovo a Smysl, 2018
The novel Severins Gang in die Finsternis (1914) by the Prague author Paul Leppin (1878–1945) is explicitly created as a city novel by the subheading Ein Prager Gespensterroman. In fact, the novel refers to specific places in Prague.
Constanze Derham
doaj  

Into a new decade [PDF]

open access: yesBehavior Research Methods, 2020
Brysbaert M.   +11 more
openaire   +3 more sources

A DECADE OF DOLICHOPODIDÆ [PDF]

open access: yesThe Canadian Entomologist, 1900
The ten species included in the present paper are all from the collection of Dr. Wm. M. Wheeler, under whose management this work was performed. As a slight token of my appreciation of his generosity and kindness, it pleases me greatly to dedicate one of the forms to him.
openaire   +3 more sources

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay   +15 more
wiley   +1 more source

Decadence @ Iklectik

open access: yes
Begemmed bodies at the end of worlds, empires in the last of their decline, and tonight, darling, we dance... This event was a one-night-only performance club night held at Iklectik Arts Lab in London.
Condé, Alice   +2 more
core   +3 more sources

« Un néant follement attifé » : macabre et grotesque dans Mesure pour Mesure

open access: yesSillages Critiques, 2013
In an anamorphic play such as Measure for Measure, the grotesque is endowed with a strong satirical power, and its close relation to the macabre makes it even stronger. Shakespeare actually depicts a dramatic vanitas and places the morbid at the heart of
Sophie Chiari
doaj   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin   +8 more
wiley   +1 more source

The imago image of ‘flowers of evil’: from Charles Baudelaire to Joris-Karl Huysmans

open access: yesСлово.ру: балтийский акцент
This article examines the image of 'flowers of evil' as an imago image — an imaginary image of a real object. The term 'imago' was first used in this sense by Carl Jung in 1912. The work proposes a novel approach to investigating the image of 'flowers of
Svetlana G. Gorbovskaya
doaj   +1 more source

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