Results 121 to 130 of about 56,576 (284)
SPG4 and Dementia: Expanding the Clinical Spectrum
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Conceived in the 16th century as one of the zannis (clownish valets) of the commedia dell’arte, Pierrot becomes a frequent theme of decadent literary works and paintings.
Eva Voldřichová Beránková
doaj
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Coletta, Michela. Decandent Modernity: Civilization and “Latinidad” in Spanish America, 1880-1920. Liverpool: Liverpool UP, 2018. 190 pp. [PDF]
Coletta, Michela. Decandent Modernity: Civilization and “ Latinidad ” in Spanish America, 1880-1920 . Liverpool: Liverpool UP, 2018.
Reynolds, Andrew
core
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
Fin-de-siècle decadence—marked by symbolism, dandyism, aesthetic withdrawal, and defiance of bourgeois norms—has long been reimagined beyond its original European contours.
Juan Wu
doaj +1 more source
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
'The Possibility of an Island' by Michel Houellebecq: a review [PDF]
A dog's life (poodles excepted): Michel Houellebecq's misanthropy is all too evident in 'The Possibility of an Island ' says Michael ...
Worton, M
core

