Molecular conformation-activity relationship of decamethonium congeners.
British Journal of Anaesthesia, 2002 BACKGROUND Of the polymethylene bismethonium congeners (C5-C12 and C18), decamethonium (C10) is the most potent neuromuscular blocking agent. We tested the hypothesis that these congeners act as straight molecules and will not bend easily in spite of the
Chingmuh Lee, T. Jones
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Allosteric Reactions of Horse Serum Cholinesterase [PDF]
, 1975 The reactions of serum cholinesterase with organic cations, such as decamethonium and atropine, as well as with inorganic cations, such as Sc3+, Eu3+, and Yb3+, have been studied.
Ljubica Kamarić
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Journal of The Experimental Analysis of Behavior, 1991 The behavioral effects of haloperidol (0.04 to 0.16 mg/kg) and nonparalytic doses of decamethonium (0.2 to 0.8 mg/kg) were studied with operant methods that permitted the measurement of response rate, peak force of response, duration of response, and ...
S. Fowler +4 more
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Spectroscopic Studies of Ligand Interactions with Acetycholinesterase [PDF]
, 1975 A series of ligands with suitable spectroscopic properties have been employed for investigating the sites and specificity of ligand association with an acetylcholinesterase purified to apparent homogeneity from Torpedo californica. Bisquaternary ammonium
Harvey Berman +3 more
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Studies on the Mode of Action of Pharmacologically Active Substances from Natural Sources with Additional Studies on Some Synthetic Neuromuscular Blocking Agents [PDF]
, 1959 Not ...
Shamsuzzoha, Mohammed
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Search for potential cholinesterase inhibitors from the zinc database by virtual screening method [PDF]
, 2015 A virtual screening of the ZINC database was applied for the identification of novel cholinesterase inhibitors. The first step allowed to select compounds with favorable physicochemical properties. Then, the compounds were screened with the pharmacophore
Bajda, Marek +5 more
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THE USE OF DECAMETHONIUM BROMIDE FOR THE PRODUCTION OF MUSCULAR RELAXATION [PDF]
, 1950 Leroy C. Harris, Robert D. Dripps
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Studies on Muscle-Tone, With Special Reference to Anaesthesia and Specific Relaxant Drugs [PDF]
, 1954 A brief historical survey of the concept of muscle-tone is given. Muscle-tone is defined as: "the capacity of a muscle to resist extension," An instrument, the Tonometer, working on the "hardness" principle, is described and assessed.
Brown, Robert Cecil
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Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses. [PDF]
Bioorg Chem, 2023 Wang R +8 more
europepmc +1 more source
Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2 [PDF]
, 2018 .: The high-affinity Na+-dependent carnitine transporter OCTN2 (SLC22A5) has a high renal expression and reabsorbs most filtered carnitine. To gain more insight into substrate specificity of OCTN2, we overexpressed hOCTN2 in L6 cells and characterized ...
Brooks, H. +6 more
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