Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2 [PDF]
, 2018 .: The high-affinity Na+-dependent carnitine transporter OCTN2 (SLC22A5) has a high renal expression and reabsorbs most filtered carnitine. To gain more insight into substrate specificity of OCTN2, we overexpressed hOCTN2 in L6 cells and characterized ...
Brooks, H. +6 more
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Molecular conformation–activity relationship of decamethonium congeners [PDF]
British Journal of Anaesthesia, 2002 Of the polymethylene bismethonium congeners (C5-C12 and C18), decamethonium (C10) is the most potent neuromuscular blocking agent. We tested the hypothesis that these congeners act as straight molecules and will not bend easily in spite of the flexible connecting chain between the methonium heads.
C, Lee, T, Jones
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Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III [PDF]
, 1982 The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction ...
Attar-Bashi, Moayad T. +6 more
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The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis [PDF]
, 2017 The scientific community will remember Peter Läuger as an exceptional man combining a generous personality and a sharp and skilful mind. He was able to attract by his views the interest of a large spectrum of biologists concerned by the mechanism of ion ...
Bertrand, Daniel +3 more
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Interaction of Ligand Binding Sites of Acetylcholinesterase [PDF]
, 1975 Ligand binding properties of acetylcholinesterase from Electrophorus electricus have been investigated under equilibrium and transient •state conditions with the reversible fluorescent probes, N-methylacridinium (N-MAC) and bis(3-aminopyridinium)-l,10 ...
David S. Sigman, Gregory Mooser
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The action of structural analogues of nicotine on synaptic transmission [PDF]
, 1961 The Relevance of Nicotine to the Study of Synaptic TransmissionI. ACTION OF NICOTINE ON TRANSMISSION IN AUTONOMIC GANGLIA: Site of Action at Ganglia 1 Chemical Transmitter 3 Identification of Acetylcholine 4 Nicotine -like Activity of Acetylcholine
Hamilton, John T.
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DECURARIZATION BY DECAMETHONIUM [PDF]
British Journal of Pharmacology and Chemotherapy, 1951 O F, HUTTER, J E, PASCOE
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The uptake of labelled decamethonium in skeletal muscle [PDF]
, 1972 Imperial Users ...
Humphrey, Patrick Paul Anthony +1 more
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Structural Changes in Acetylcholinesterase under the Influence of Some Ligands [PDF]
, 1975 In order to elucidate the nature of the effect of some ligands on the methanesulfonylation of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7), the methanesulfonylation of the enzyme was studied, in the absence and presence of ligands, at
Miloš R. Pavlič
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Isolation of a Housefly Head Protein Fraction that Exhibits High Affinity Binding of Cholinergic Ligands [PDF]
, 1975 The purification is described of a protein fraction, isolated from the central nervous system of housefly heads, that exhibits high affinity for cholinergic ligands.
Barry S. Clarke +2 more
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