Results 41 to 50 of about 464,513 (260)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Indian Journal of Dental Research, 2020 Background: Dental caries is a dysbiotic polymicrobial disease that can cause damage to an individual's successful, elite sporting performance. Aims: This study aimed to realize a meta-analysis to calculate a worldwide, pooled estimated prevalence of ...
Fellipe Navarro Azeredo +5 more
doaj +1 more source
Tennyson’s Wrinkled Feet: Ageing and the Poetics of Decay
19, 2021 This article argues that Tennyson’s ‘Tithonus’ (1860) draws together ageing and decay through the poem’s formal wrinkling: moments where metrical disruption, folding, slackness, or concealment correspond to the insights derived from the perspective of ...
Jacob Jewusiak
doaj +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Diffusion of gases dissolved in peat pore water [PDF]
Mires and Peat, 2012 Diffusion is usually thought to be ineffective at transporting solutes over distances of several metres – the depth of many peat deposits. But this is to neglect the importance of time. We derive equations that show that in peat that has accumulated over
R.S. Clymo, M.M.R. Williams
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Experimental and CFD Investigation on the Application for Aerogel Insulation in Buildings
Energies, 2021 Reducing building energy consumption is a significant challenge and is one of the most important research areas worldwide. Insulation will help to keep the building’s desired temperature by reducing the heat flow.
Santu Golder +3 more
doaj +1 more source
International Journal of Modern Physics A, 2001 An effective theory of large NC QCD of mesons has been used to study six Kl4 decay modes. PCAC is satisfied. A relationship between three form factors of axial-vector current has been found. ρ → ππ plays important role. the decay rates are calculated in the chiral limit. There is no adjustable parameter.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Periodontal Diseases and Dental Caries in Children With Cerebral Palsy [PDF]
Iranian Rehabilitation Journal, 2021 Objectives: Musculoskeletal disorders in children with Cerebral Palsy (CP) affect the general health of the mouth and teeth. This study aimed to determine periodontal and dental diseases in children with CP based on gross motor function level, manual ...
Hamid Dalvand +4 more
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